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Visceral Involvement by Herpes Simplex Virus in Eczema Herpeticum

Gilles R. G. Monif, MD; Philip A. Brunell, MD; G. D. Hsiung, PhD
Am J Dis Child. 1968;116(3):324-327. doi:10.1001/archpedi.1968.02100020326018.
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ECZEMA herpeticum is a primary herpetic infection which characteristically occurs in patients with eczema or other skin conditions. This entity may be complicated by the development of meningoencephalitis.1-4 In Kaposi's original description of eczema herpeticum, one of the six cases had overt neurological disease.1 Wenner subsequently isolated herpes simplex virus from both cutaneous scrapings and brain suspension of a 5-month-old infant whose hospital course had been complicated by clonictonic movements in the upper extremities and seizures.3 Pugh et al demonstrated typical herpetic lesions in and recovered herpes simplex virus from the skin of a fatal case of eczema herpeticum in an 11½-month-old infant.5 Necropsy revealed evidence of hematogenous dissemination of the virus to the adrenals, as well as atypical focal pulmonary necrosis. This report describes visceral involvement by herpes simplex virus in a 5-month-old infant with eczema herpeticum and probable central nervous system (CNS) involvement who, 16


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