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Failure of Cephaloridine in Hemophilus influenzae Meningitis

Stuart H. Walker, MD; Chester C. Collins Jr., MD
Am J Dis Child. 1968;116(3):285-291. doi:10.1001/archpedi.1968.02100020287009.
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CEPHALORIDINE, a semisynthetic derivative of cephalosporin, has been demonstrated to have in vitro activity against Hemophilus influenzae.1,2 Nonmeningeal infections with H influenzae have been successfully treated.3 Few reports of its clinical use in meningitis are available, but significant spinal fluid penetration has been demonstrated in the presence and absence of meningeal inflammation.4,5

This report describes the use of cephaloridine in the treatment of three infants with H influenzae meningitis and provides data on the spinal fluid penetration, effectiveness, and toxicity of this antibiotic at high dosage levels in meningeal disease.

Materials and Methods  Three infants with H influenzae meningitis were treated with cephaloridine on the Pediatric Service, Mercy Hospital, Baltimore. Hemophilus influenzae was initially isolated on chocolate agar from the cerebrospinal fluid (CSF) or blood or both of each patient. The minimum inhibitory concentration (MIC) of cephaloridine for each organism was determined by the tube dilution


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