0
Article |

Imipramine Hydrochloride Poisoning in Childhood FREE

Robert Penny, MC, USAF
[+] Author Affiliations

Received for publication Oct 16, 1967.

The views expressed herein are those of the author and do not necessarily reflect the views of the United States Air Force or the Department of Defense.

Reprint requests to Department of Pediatrics, Johns Hopkins Hospital, 601 N Broadway, Baltimore 21205.


Am J Dis Child. 1968;116(2):181-186. doi:10.1001/archpedi.1968.02100020183011.
Text Size: A A A
Published online

IMIPRAMINE hydrochloride (Tofranil) is currently being used in childhood for the treatment of enuresis.1 There are few reported cases of imipramine poisoning in childhood. A review of the literature has revealed only 17. The present report concerns the successful management, with potassium chloride, of the cardiac disturbances in a child with imipramine poisoning.

Report of a Case  A 31/12-year-old white boy was transferred to March AFB Hospital because of coma and convulsions. Four days prior to admission, he had fallen and lacerated the right side of his forehead. He seemed well until 5:30 pm on the day of admission, when he developed hysterical behavior followed by a generalized convulsion. At 5:45 pm, he was seen in the emergency room of the local hospital, where a second generalized convulsion occurred. Examination of the unconscious child revealed that the right pupil reacted to light, the left pupil was dilated and fixed,

REFERENCES

Poussaint, A.F., and Ditman, K.S.:  Controlled Study of Imipramine (Tofranil) in Treatment of Childhood Enuresis , J Pediat 67:283-290 ( (Aug) ) 1965;.
Goodman, L., and Gillman, A.: The Pharmacologic Basis of Therapeutics , ed 3, New York: MacMillan Co., 1960;.
Frankel, S., and Reitman, S.: Gradwohl's Clinical Laboratory Methods and Diagnosis , ed 6, St. Louis: C. V. Mosby Co., vol 1, 1963;.
Alajem, N., and Albagli, C.H.:  Severe Imipramine Poisoning in an Infant , Amer J Dis Child 103:702-705 ( (May) ) 1962;.
Carncross, K.D., and Gershon, S.:  Pharmacologic Basis of the Cardiovascular Complications of Imipramine , Med J Aust 2:372-375 ( (Sept) ) 1962;.
Connelly, J.F., and Venables, A.W.:  Case of Poisoning With Tofranil , Med J Aust 1:108 ( (Jan) ) 1961;.
Garrison, H.F., et al:  Imipramine Intoxication , JAMA 179:456-458 ( (Feb 21) ) 1962;.
Giles, H.M.C.:  Imipramine Poisoning in Childhood , Brit Med J 2:844-846 ( (Oct) ) 1963;.
Noack, C.H.:  Death From Overdosage of Tofranil , Med J Aust 2:182 ( (July) ) 1960;.
Prout, B.J., et al:  Imipramine Poisoning in Childhood and Suggested Treatment , Brit Med J 1: 972 ( (April) ) 1965;.
Jacobiziner, H.:  Accidental Chemical Poisonings , New York J Med 63:1394-1397 ( (May) ) 1963;.
Dingell, J.V., et al:  Species Differences in the Metabolism of Imipramine and Desmethylimipramine , J Pharmacol Exp Ther 143:14-22 ( (Jan) ) 1963;.
Fruthaler, G.J., and Snyder, C.H.:  Poisoning in Childhood , Pediat Clin N Amer 9:41-66 ( (Feb) ) 1962;.
Harthorne, J.W., et al:  Management of Massive Imipramine Overdosage With Mannitol and Artificial Dialysis , New Eng J Med 268:33-35 ( (Jan) ) 1963;.
Tave, V., and Brechtlove, M.:  Effects of Imipramine and Ouabain on the (Na+ + K+) Activated ATPase From Brain Microsomes and Co-Operative Interaction With the Enzyme , J Neurochem 14:283-290 ( (March) ) 1967;.
Arneson, G.A.:  Near Fatal Case of Imipramine Overdosage , Amer J Psychiat 117:934-936 ( (April) ) 1961;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Poussaint, A.F., and Ditman, K.S.:  Controlled Study of Imipramine (Tofranil) in Treatment of Childhood Enuresis , J Pediat 67:283-290 ( (Aug) ) 1965;.
Goodman, L., and Gillman, A.: The Pharmacologic Basis of Therapeutics , ed 3, New York: MacMillan Co., 1960;.
Frankel, S., and Reitman, S.: Gradwohl's Clinical Laboratory Methods and Diagnosis , ed 6, St. Louis: C. V. Mosby Co., vol 1, 1963;.
Alajem, N., and Albagli, C.H.:  Severe Imipramine Poisoning in an Infant , Amer J Dis Child 103:702-705 ( (May) ) 1962;.
Carncross, K.D., and Gershon, S.:  Pharmacologic Basis of the Cardiovascular Complications of Imipramine , Med J Aust 2:372-375 ( (Sept) ) 1962;.
Connelly, J.F., and Venables, A.W.:  Case of Poisoning With Tofranil , Med J Aust 1:108 ( (Jan) ) 1961;.
Garrison, H.F., et al:  Imipramine Intoxication , JAMA 179:456-458 ( (Feb 21) ) 1962;.
Giles, H.M.C.:  Imipramine Poisoning in Childhood , Brit Med J 2:844-846 ( (Oct) ) 1963;.
Noack, C.H.:  Death From Overdosage of Tofranil , Med J Aust 2:182 ( (July) ) 1960;.
Prout, B.J., et al:  Imipramine Poisoning in Childhood and Suggested Treatment , Brit Med J 1: 972 ( (April) ) 1965;.
Jacobiziner, H.:  Accidental Chemical Poisonings , New York J Med 63:1394-1397 ( (May) ) 1963;.
Dingell, J.V., et al:  Species Differences in the Metabolism of Imipramine and Desmethylimipramine , J Pharmacol Exp Ther 143:14-22 ( (Jan) ) 1963;.
Fruthaler, G.J., and Snyder, C.H.:  Poisoning in Childhood , Pediat Clin N Amer 9:41-66 ( (Feb) ) 1962;.
Harthorne, J.W., et al:  Management of Massive Imipramine Overdosage With Mannitol and Artificial Dialysis , New Eng J Med 268:33-35 ( (Jan) ) 1963;.
Tave, V., and Brechtlove, M.:  Effects of Imipramine and Ouabain on the (Na+ + K+) Activated ATPase From Brain Microsomes and Co-Operative Interaction With the Enzyme , J Neurochem 14:283-290 ( (March) ) 1967;.
Arneson, G.A.:  Near Fatal Case of Imipramine Overdosage , Amer J Psychiat 117:934-936 ( (April) ) 1961;.

Correspondence

CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.