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Long-Term Therapy of Chronic Urinary Tract Infection in Children

Donald Kaye, MD; Nicholas J. Vianna, MD; John H. McGovern, MD; Henry R. Shinefield, MD; Melvin Rosh, MD
Am J Dis Child. 1968;116(2):166-174. doi:10.1001/archpedi.1968.02100020168008.
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TREATMENT of patients with chronic urinary tract infection is often unsuccessful.1-3 Urological investigation frequently reveals anatomic abnormalities of the urinary tract which further reduce the chances of successful therapy.1,2

Several investigators4-6 have recommended prolonged antimicrobial therapy for chronic urinary tract infection. However, other studies7,8 have shown no advantage with prolonged therapy. Turck et al9 separated patients in whom treatment was unsuccessful into those who relapsed with bacteriuria due to the same microorganism and those who became reinfected with a different microorganism. These investigators recommended therapy for six weeks or more in those patients who relapsed but felt that prolongation of therapy was of no value in patients who tended to develop reinfection. Still other investigators10 have suggested that prolonged antimicrobial therapy may be of value in patients who tend to become reinfected, and may act as prophylaxis to prevent reinfection.

The present investigation was undertaken to evaluate

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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