August 1968, Vol 116, No. 2 >

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Article | August 1968

Long-Term Therapy of Chronic Urinary Tract Infection in Children

Donald Kaye, MD; Nicholas J. Vianna, MD; John H. McGovern, MD; Henry R. Shinefield, MD; Melvin Rosh, MD

Am J Dis Child. 1968;116(2):166-174. doi:10.1001/archpedi.1968.02100020168008.

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TREATMENT of patients with chronic urinary tract infection is often unsuccessful.^1-3 Urological investigation frequently reveals anatomic abnormalities of the urinary tract which further reduce the chances of successful therapy.^1,2

Several investigators^4-6 have recommended prolonged antimicrobial therapy for chronic urinary tract infection. However, other studies^7,8 have shown no advantage with prolonged therapy. Turck et al⁹ separated patients in whom treatment was unsuccessful into those who relapsed with bacteriuria due to the same microorganism and those who became reinfected with a different microorganism. These investigators recommended therapy for six weeks or more in those patients who relapsed but felt that prolongation of therapy was of no value in patients who tended to develop reinfection. Still other investigators¹⁰ have suggested that prolonged antimicrobial therapy may be of value in patients who tend to become reinfected, and may act as prophylaxis to prevent reinfection.

The present investigation was undertaken to evaluate

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Kaye D, Vianna NJ, McGovern JH, Shinefield HR, Rosh M. Long-Term Therapy of Chronic Urinary Tract Infection in Children. Am J Dis Child. 1968;116(2):166-174. doi:10.1001/archpedi.1968.02100020168008.

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