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Smaller G (Gp−) and t (Gp−; Dp+) Acute Leukemia

Kong-oo Goh, MD
Am J Dis Child. 1968;115(6):732-738. doi:10.1001/archpedi.1968.02100010734018.
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A SMALLER G chromosome, probably evolved from a deletion of the short arm of a normal G chromosome, has been reported in familial chronic lymphocytic leukemia (CLL), and is called "Ch1" or "Christchurch" chromosome.1 The purpose of this communication is to report a morphologically similar abnormal chromosome in a family; but in addition, the deleted short arm of the G chromosome is apparently translocated to the short arm of a D chromosome.

Report of a Case  The patient is a phenotypically normal 4½-year-old girl who was in good health until four weeks before admission when she developed easy fatigability and difficulty in walking. The family history is not remarkable and the pedigree is summarized in Fig 1. Physical examination revealed pallor, a grade 2 systolic apical murmur, hepatomegaly, and palpable lymph nodes in the cervical, left axillary, and inguinal regions. The spleen was not palpable. Laboratory studies disclosed


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