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Cytogenic Studies in Metastatic Neuroblastoma

Jacqueline Whang-Peng, MD; John M. Bennett, MD
Am J Dis Child. 1968;115(6):703-708. doi:10.1001/archpedi.1968.02100010705010.
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HIGH incidence of nonspecific abnormal chromosomes in human malignant tumors was noticed in the past ten years.1 To date the finding of the minute chromosome (Ph1) in the bone marrow of patients with chronic myelogenous leukemia represents the only instance of a specific chromosome abnormality unique to a human neoplastic disease.2-5 A recent case of metastatic neuroblastoma with unusual chromosome abnormalities in the direct bone marrow preparation prompted us to review our experience with two additional cases in the hope that some common abnormality would be found.

Materials and Methods  The following three patients with disseminated neuroblastoma were treated at the Clinical Center, National Cancer Institute, National Institutes of Health. Chromosomes of the mitotic cells in bone marrow were studied without prior in vitro culture and in air dried preparations.6 Peripheral blood was cultured for 72 hours and preparations made according to the technique of Moorhead


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