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Clinical Trial of Live Attenuated Rubella Virus Vaccine, HPV-77 Strain

Louis Z. Cooper, MD; Joan P. Giles, MD; Saul Krugman, MD
Am J Dis Child. 1968;115(6):655-657. doi:10.1001/archpedi.1968.02100010657003.
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IN 1966, Parkman, Meyer, and their colleagues described preliminary vaccine trials with a strain of rubella virus which had been attenuated by 77 passages in primary African green monkey kidney (AGMK) tissue culture.1,2 This strain, designated HPV-77, exhibited desirable qualities of immunogenicity and obvious attenuation in man. The present report describes our experience with HPV-77 virus in a series of vaccine trials which involved 48 children.

Materials and Methods  Vaccine.—The details of the preparation and safety testing of HPV-77 vaccine have been described by Meyer et al.1,2 The vaccine was supplied in single-dose vials which were stored at −65 C until use. Each vaccinated child received rubella vaccine (HPV-77), 0.5 ml subcutaneously. This dose represented 500 tissue culture interfering doses50 (TCID50), based on a titration in primary AGMK tissue culture using echovirus type 11 challenge.3Study Population and Experimental Design.—The 48 children were admitted


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