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Hypocalcemia and Cardiac Arrhythmias

John D. Johnson, MD; Rufus Jennings, MD
Am J Dis Child. 1968;115(3):373-376. doi:10.1001/archpedi.1968.02100010375014.
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THE BEST KNOWN clinical effect on the heart of hypocalcemia is prolongation of the QT interval, ie, prolongation of electrical systole.1-6 Only recently has cardiac arrhythmia been reported as a clinical manifestation of hypocalcemia.7,8 This report describes a child with hypocalcemic vitamin D deficient rickets who presented with bizarre cardiac arrhythmias which were corrected following oral calcium and vitamin D2 therapy.

Report of a Case  This 5½-year-old Negro boy was admitted to the Johns Hopkins Hospital because of tachycardia discovered during a routine visit to the cardiac clinic. He had been followed by the Growth and Development Program of Johns Hopkins Hospital since age 4 months, and had been noted to have marked motor and mental retardation. In addition, a heart murmur had been heard consistently since 1 year of age. Previous chest x-ray films had revealed mild cardiac enlargement and an electrocardiogram had shown right ventricular


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