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Convulsion as a Presenting Sign of Infectious Mononucleosis

Richard J. Bonforte, MD
Am J Dis Child. 1967;114(4):429-432. doi:10.1001/archpedi.1967.02090250127015.
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NEUROLOGIC manifestations of infectious mononucleosis in the adult are well documented.1 The first pediatric report of such manifestations was by Geliebter in 1946.2 Since that publication, documented cases have appeared with some regularity.3-6 As evidence of central nervous system involvement, however, the association of seizures and mononucleosis is uncommon in children and adults. Lazar et al in 1956 were able to collect only 13 such cases and there was only one pediatric case included in this review.7 Convulsion as a presenting sign of infectious mononucleosis is even more uncommon. Silver et al5 have had the only such case report in the pediatric literature.

Recently we observed a 4-year-old child with infectious mononucleosis who presented with a seizure. The cause of the seizure and the diagnosis of mononucleosis were suggested by alterations in the cerebrospinal fluid. This case is being reported not only because of the


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