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Phenylketonuria in Two American Negroes

Robert G. Graw Jr., MD; Richard Koch, MD
Am J Dis Child. 1967;114(4):412-418. doi:10.1001/archpedi.1967.02090250110011.
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THERE HAVE BEEN few reports of phenylketonuria (PKU) in thoroughly-studied American Negroes, with and without known white admixture.1-4 As yet there are no reports of phenylketonuria occurring in Negroes in the Western United States. Glass and Li predicted that phenylketonuria in the North American Negro should be one-ninth as frequent as in the whites. They based their estimate upon the accumulated white admixture to the Negro race thought to be about 30%.5 The previous reports of patients in Negro families have generally involved admitted Indian or white admixture. This report describes an American Negro family from Southern California with two phenylketonuric children with no admitted white background. Many characteristics of this family suggest that white admixture had previously occurred, but with intensive investigation this could not be verified.

Report of Cases  Case 1.—The patient was referred to Children's Hospital of Los Angeles for evaluation and treatment of phenylketonuria


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