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Clinical Comparison of Three Antipyretic Agents

Alvin N. Eden, MD; Arthur Kaufman, MD
Am J Dis Child. 1967;114(3):284-287. doi:10.1001/archpedi.1967.02090240098007.
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FEVER is one of the most frequently encountered problems facing the pediatrician. Often he prescribes an antipyretic agent in conjunction with treatment for the basic disease.

The purpose of this study was to compare the antipyretic efficacy of three commonly used drugs: acetaminophen, aspirin, and salicylamide. We also wanted to determine whether there were any differences in the onset, peak, and duration of action of these drugs.

Method of Study  The study included 150 infants and children, each with a minimum temperature of 102 F (38.9 C). They were divided into three groups: A, B, and C. Each group contained 50 patients. Random selection was used in determining which group a patient would join.The patients in group A received acetaminophen; group B, aspirin; group C, salicylamide. The patients had received no antipyretic therapy for at least four hours prior to the start of the observation period.One of the


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