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Acute Encephalopathy and Fatty Hepatomegaly

William D. Bradford, MD; William C. Latham, MD
Am J Dis Child. 1967;114(2):152-156. doi:10.1001/archpedi.1967.02090230082008.
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A SYNDROME of encephalopathy and fatty liver has been the subject of recent reports in the pediatric literature.1-3 This encephalitis-like illness has rather characteristic clinical and pathological findings which are not new and were descrbed by Brain et al in 1929.4 Whether or not the combination of acute encephalopathy and fatty change in the liver is specific and deserves consideration as an entity is open to question. Using an illustrative case from our own material, we should like to review the clinical, laboratory, and anatomic features of similar cases available in the literature.

Report of a Case  Three days prior to admission July 21, 1965, a 3-year-old white boy developed an upper respiratory tract infection with cough. Two days prior to admission, he began to vomit and was febrile. On the day of admission, he progressed from irritability to drowsiness and coma. His temperature was 103 F (39.4


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