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Hereditary Nephropathy Without Deafness

Robert J. Dockhorn, MC, USN
Am J Dis Child. 1967;114(2):135-138. doi:10.1001/archpedi.1967.02090230065004.
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HEMATURIA is a relatively common finding in a general pediatric practice. The occurrence of hematuria in more than one member of the family is not extremely uncommon. This may represent nephritis due to a simultaneous infection of several members of a family by a nephritogenic type of Streptococcus. However, when the hematuria occurs in three or more generations of a family, a hereditary or familial type of nephritis is probable. There have been less than 30 kindred reported with nephritis in three or more generations.1 The majority of these reports describe other associated disorders in addition to the hematuria. There have been only a few sporadic reports of hereditary hematuria alone.

The reports of hereditary hematuria suggest five separate clinical groups. (1) Hereditary hematuria characterized by hematuria, albuminuria, red blood cell casts with exacerbations due to infections, and a pathological picture resembling acute and chronic glomerulonephritis. Nerve deafness is


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