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Adrenocortical Carcinoma With Virilism in an Infant Under 1 Year of Age

John D. Cooper, MC; Leonard Maldonado, MC; Jerry M. Earll, MC
Am J Dis Child. 1967;113(6):730-732. doi:10.1001/archpedi.1967.02090210144019.
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ADRENAL HORMONE producing neoplasms in infancy are rare; however, the limited literature reflects a poor, but by no means hopeless, prognosis.1,2 Only one case of virilism due to adrenocortical carcinoma, with surgical cure, has been reported in an infant under 1 year of age.3 This paper describes a virilized infant with adrenal cortical carcinoma who is presumptively cured after surgical excision of the tumor.

Report of a Case  A 10½-month-old white female was admitted to William Beaumont General Hospital on April 14, 1964, because of pubic hair growth of one month's duration. She was born at this hospital after an uncomplicated pregnancy. The birth weight was 2.9 kg (6 lb 4 oz) and she was judged to be a normal infant. Routine examinations at 6 weeks and 3 months revealed normal growth and development. At 9½ months of age, growth of pubic hair began, and medical advice was


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