0
June 1967, Vol 113, No. 6 >
Article | June 1967

Reversible Secondary Disaccharidase Deficiency FREE

J. D. Welsh, MD; M. G. Porter, MD
[+] Author Affiliations

Received for publication Sept 30, 1966.

Reprint requests to Department of Medicine, University of Oklahoma Medical Center, 800 NE 13th St, Oklahoma City 73104 (Dr. Welsh).


Am J Dis Child. 1967;113(6):716-720. doi:10.1001/archpedi.1967.02090210130016.
Text Size: A A A
Published online
Article
References
Comments

DIETARY disaccharides are hydrolyzed by specific enzymes in the brush border membrane of the small intestinal surface epithelial cells.1 Disaccharide malabsorption may be primary and result from the congenital or acquired absence of a specific functional element of the digestive-absorptive surface or may be secondary and caused by a reduction in the total available digestive-absorptive surface, as a consequence of other disease.2 Young children whose initial symptoms are consistent with gastroenteritis may develop a temporary secondary disaccharidase deficiency associated with intestinal mucosal damage.3 This report will present such a patient and discuss the confusion that may arise in diagnosis, if complete studies are not performed.

Methods  Oral carbohydrate-tolerance tests were performed in a uniform fashion using 2 gm of sugar per kilogram of body weight. The blood sugar was determined in duplicate by the Nelson-Somogyi method4 on samples obtained from the fasting patient and at one-half

REFERENCES

1 +
Miller, D., and Crane, R.K.:  The Digestive Function of the Epithelium of the Small Intestine: I. An Intracellular Locus of Disaccharide and Sugar Phosphate Ester Hydrolysis , Biochim Biophys Acta 52:281, 1961;.
2 +
Crane, R.K.:  Enzymes and Malabsorption: A Concept of Brush Border Membrane Disease , Gastroenterology 50:254, 1966;.
3 +
Burke, V.; Kerry, K.R.; and Anderson, C.M.:  The Relationship of Dietary Lactose to Refractory Diarrhea in Infancy , Aust Paediat J 1:147, 1965;.
4 +
Nelson, N.:  A Photometric Adaptation of the Somogyi Method for the Determination of Glucose , J Biol Chem 153:375, 1944;.
5 +
Bickel, H.:  Mellituria, a Paper Chromatographic Study , J Pediat 59:641, 1961;.
6 +
Roe, J.H., and Rice, E.W.:  A Photometric Method for the Determination of Free Pentoses in Animal Tissues , J Biol Chem 173:507, 1948;.
7 +
Van de Kamer, J.H.; ten Bokkel Huinink, H.; and Weyers, H.A.:  Rapid Method for the Determination of Fat in Feces , J Biol Chem 177:347, 1949;.
8 +
Welsh, J.D.; Rohrer, G.V.; and Porter, M.G.:  The Baker-Hughes Gastrointestinal Biopsy Tube , Amer J Dig Dis 11:559, 1966;.
9 +
Dahlqvist, A.:  Method for Assay of Intestinal Disaccharidases , Anal Biochem 7:18, 1964;.
10 +
Klein, R.; Read, P.A.; and Babson, A.L.:  Rapid Method for the Quantitative Determination of Serum Alkaline Phosphatase , Clin Chem 6:269, 1960;.
11 +
Lowry, O.H., et al:  Protein Measurement With the Folin Phenol Reagent , J Biol Chem 193:265, 1951;.
12 +
Welsh, J.D., et al:  Human Intestinal Disaccharidase Activity: II. Diseases of the Small Intestine and Deficiency States , Arch Intern Med 117:495, 1966;.
13 +
Sunshine, P., and Kretchmer, N.:  Studies of Small Intestine During Development: III. Infantile Diarrhea Associated With Intolerance to Disaccharides , Pediatrics 34:38, 1964;.
14 +
Lifshitz, F., and Holman, G.H.:  Disaccharidase Deficiencies With Steatorrhea , J Pediat 64:34, 1964;.
15 +
Anyon, C.P., and Clarkson, K.G.:  Lactose Absorption in the Neonate , New Zeal Med J 64:694, 1965;.
16 +
Boellner, S.W.; Beard, A.G.; and Panos, T.C.:  Impairment of Intestinal Hydrolysis of Lactose in Newborn Infants , Pediatrics 36:542, 1965;.
17 +
Auricchio, S.; Rubino, A.; and Mürset, G.:  Intestinal Glycosidase Activities in the Human Embryo, Fetus, and Newborn , Pediatrics 35:944, 1965;.
18 +
Holzel, A.; Mereu, T.; and Thomson, M.L.:  Severe Lactose Intolerance in Infancy , Lancet 2:1346, 1962;.
19 +
Knudsen, K.B., et al:  The Influence of Fasting and Refeeding on Jejunal Disaccharidases , abstracted; Clin Res 14:87, 1966;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Miller, D., and Crane, R.K.:  The Digestive Function of the Epithelium of the Small Intestine: I. An Intracellular Locus of Disaccharide and Sugar Phosphate Ester Hydrolysis , Biochim Biophys Acta 52:281, 1961;.
2 +
Crane, R.K.:  Enzymes and Malabsorption: A Concept of Brush Border Membrane Disease , Gastroenterology 50:254, 1966;.
3 +
Burke, V.; Kerry, K.R.; and Anderson, C.M.:  The Relationship of Dietary Lactose to Refractory Diarrhea in Infancy , Aust Paediat J 1:147, 1965;.
4 +
Nelson, N.:  A Photometric Adaptation of the Somogyi Method for the Determination of Glucose , J Biol Chem 153:375, 1944;.
5 +
Bickel, H.:  Mellituria, a Paper Chromatographic Study , J Pediat 59:641, 1961;.
6 +
Roe, J.H., and Rice, E.W.:  A Photometric Method for the Determination of Free Pentoses in Animal Tissues , J Biol Chem 173:507, 1948;.
7 +
Van de Kamer, J.H.; ten Bokkel Huinink, H.; and Weyers, H.A.:  Rapid Method for the Determination of Fat in Feces , J Biol Chem 177:347, 1949;.
8 +
Welsh, J.D.; Rohrer, G.V.; and Porter, M.G.:  The Baker-Hughes Gastrointestinal Biopsy Tube , Amer J Dig Dis 11:559, 1966;.
9 +
Dahlqvist, A.:  Method for Assay of Intestinal Disaccharidases , Anal Biochem 7:18, 1964;.
10 +
Klein, R.; Read, P.A.; and Babson, A.L.:  Rapid Method for the Quantitative Determination of Serum Alkaline Phosphatase , Clin Chem 6:269, 1960;.
11 +
Lowry, O.H., et al:  Protein Measurement With the Folin Phenol Reagent , J Biol Chem 193:265, 1951;.
12 +
Welsh, J.D., et al:  Human Intestinal Disaccharidase Activity: II. Diseases of the Small Intestine and Deficiency States , Arch Intern Med 117:495, 1966;.
13 +
Sunshine, P., and Kretchmer, N.:  Studies of Small Intestine During Development: III. Infantile Diarrhea Associated With Intolerance to Disaccharides , Pediatrics 34:38, 1964;.
14 +
Lifshitz, F., and Holman, G.H.:  Disaccharidase Deficiencies With Steatorrhea , J Pediat 64:34, 1964;.
15 +
Anyon, C.P., and Clarkson, K.G.:  Lactose Absorption in the Neonate , New Zeal Med J 64:694, 1965;.
16 +
Boellner, S.W.; Beard, A.G.; and Panos, T.C.:  Impairment of Intestinal Hydrolysis of Lactose in Newborn Infants , Pediatrics 36:542, 1965;.
17 +
Auricchio, S.; Rubino, A.; and Mürset, G.:  Intestinal Glycosidase Activities in the Human Embryo, Fetus, and Newborn , Pediatrics 35:944, 1965;.
18 +
Holzel, A.; Mereu, T.; and Thomson, M.L.:  Severe Lactose Intolerance in Infancy , Lancet 2:1346, 1962;.
19 +
Knudsen, K.B., et al:  The Influence of Fasting and Refeeding on Jejunal Disaccharidases , abstracted; Clin Res 14:87, 1966;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems