0
June 1967, Vol 113, No. 6 >
Article | June 1967

Comparison of Endogenous Creatinine Clearance With Inulin Clearance FREE

Warren F. Dodge, MD; Luther B. Travis, MD; C. William Daeschner, MD
[+] Author Affiliations

Received for publication Aug 11, 1966.

Read before the annual meeting of the Southern Society for Pediatric Research, Louisville, November 1965.

Reprint requests to University of Texas Medical Center, Galveston, Tex 77551 (Dr. Dodge).


Am J Dis Child. 1967;113(6):683-692. doi:10.1001/archpedi.1967.02090210097010.
Text Size: A A A
Published online
Article
References
Comments

IN CLINICAL investigations requiring estimation of glomerular filtration rate (GFR), it is desirable that the technique employed be both reliable and convenient. The clearance of inulin is generally accepted as the most accurate method for measuring rate of glomerular filtration. In prolonged studies, however, the frequent or serial determination of inulin clearance presents certain problems of convenience to both investigator and patient and it would be highly advantageous if some simple but equally reliable method was available.

The search for a convenient clinical method has centered principally upon the clearance of urea and creatinine. Urea was discarded when its rate of clearance was shown to be less than inulin and dependent upon rate of urine flow.1 Endogenous creatinine is a normal end-product of creatine metabolism.2 Its daily production and urinary excretion in normal subjects is relatively proportional to lean body mass.2-4 Our findings are consistent with the

REFERENCES

1 +
Van Slyke, D.D.; Hiller, A.; and Miller, B.F.:  The Clearance, Extraction Percentage, and Estimated Filtration of Sodium Ferrocyanide in the Mammalian Kidney: Comparison of Inulin, Creatinine, and Urea , Amer J Physiol 113:611-628, 1935;.
2 +
Hoberman, H. D.; Sims, E.A.; and Peters, J.H.:  Creatine and Creatinine Metabolism in the Normal Adult Male Studied With the Aid of Isotopic Nitrogen , J Biol Chem 172:45-58, 1948;.
3 +
Doolan, P.D.; Alpen, E.L.; and Theil, G.P.:  A Clinical Appraisal of the Plasma Concentration and Endogenous Clearance of Creatinine , Amer J Med 32:65-79, 1962;.
4 +
Hobson, W.:  Urinary Output of Creatine and Creatinine Associated With Physical Exercise, and Its Relationship to Carbohydrate Metabolism , Biochem J 33:1425-1431, 1939;.
5 +
Findley, T., Jr.:  The Excretion of Endogenous 'Creatinine' by the Human Kidney , Amer J Physiol 123:260-265, 1938;.
6 +
Brod, J., and Sirota, J.H.:  The Renal Clearance of Endogenous 'Creatinine' in Man , J Clin Invest 27:645-654, 1948;.
7 +
Steinitz, K., and Türkand, H.:  The Determination of Glomerular Filtration by the Endogenous Creatinine Clearance , J Clin Invest 19:285-298, 1940;.
8 +
Bonsnes, R.W., and Taussky, H.H.:  On the Colorimetric Determination of Creatinine by the Jaffe Reaction , J Biol Chem 158:581-591, 1945;.
9 +
Hare, R.S.:  Endogenous Creatinine in Serum and Urine , Proc Soc Exp Biol Med 74:148-151, 1950;.
10 +
Polar, E., and Metcoff, J.:  'True' Creatinine Chromogen Determination in Serum and Urine by Semi-Automated Analysis , Clin Chem 11:763-770, 1965;.
11 +
Mattar, G., et al:  Measurement of Glomerular Filtration Rate in Children With Kidney Disease , J Clin Invest 31:938-946, 1952;.
12 +
Dodge, W.F., and Daeschner, C.W.:  Factors Influencing the Short-Term Measurement of Glomerular Filtration Rate by Endogenous Creatinine Clearance , Clin Res 8:62, 1960;.
13 +
Ikkos, D., and Strom, L.:  A Comparison of the Endogenous Creatinine and Inulin Clearances in Children , Acta Paediat (Stockholm) 44:426-434, 1955;.
14 +
Berlyne, G.M., et al:  Endogenous-Creatinine Clearance and Glomerular-Filtration Rate , Lancet 2:874-876, 1964;.
15 +
Vere, D.W., and Walduck, A.:  Endogenous-Creatinine Clearance and Glomerular-Filtration Rate , Lancet 2:1299, 1964;.
16 +
Berlyne, G.M.:  Endogenous Creatinine Clearance and the Glomerular Filtration Rate , Amer Heart J 70:143-145, 1965;.
17 +
Hawk, P.B.; Oser, B.L.; and Summerson, W.H.: Practical Physiological Chemistry , ed 13, New York: McGraw-Hill Book Co., Inc. 1954;, p 900.
18 +
Folin, O., and Morris, J.L.:  On the Determination of Creatinine and Creatine in Urine , J Biol Chem 17:469-473, 1914;.
19 +
Schreiner, G.E:  Determination of Inulin by Means of Resorcinol , Proc Soc Exp Biol Med 74:117-120, 1950;.
20 +
Sirota, J.H.; Baldwin, D.S.; and Villarreal, H.:  Diurnal Variations of Renal Function in Man , J Clin Invest 29:187-192, 1950;.
21 +
Best, W.R.; Kuhl, W.H., Jr.; and Friedemann, T.E.:  Diurnal Trend and Variation of Urinary Creatinine Excretion , Fed Proc 11:188, 1952;.
22 +
Shannon, J.A.:  The Renal Excretion of Creatinine in Man , J Clin Invest 14:403-410, 1935;.
23 +
Enger, E., and Blegen, E.M.:  The Relationship Between Endogenous Creatinine Clearance and Serum Creatinine in Renal Failure , Scand J Clin Lab Invest 16:273-280, 1964;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Van Slyke, D.D.; Hiller, A.; and Miller, B.F.:  The Clearance, Extraction Percentage, and Estimated Filtration of Sodium Ferrocyanide in the Mammalian Kidney: Comparison of Inulin, Creatinine, and Urea , Amer J Physiol 113:611-628, 1935;.
2 +
Hoberman, H. D.; Sims, E.A.; and Peters, J.H.:  Creatine and Creatinine Metabolism in the Normal Adult Male Studied With the Aid of Isotopic Nitrogen , J Biol Chem 172:45-58, 1948;.
3 +
Doolan, P.D.; Alpen, E.L.; and Theil, G.P.:  A Clinical Appraisal of the Plasma Concentration and Endogenous Clearance of Creatinine , Amer J Med 32:65-79, 1962;.
4 +
Hobson, W.:  Urinary Output of Creatine and Creatinine Associated With Physical Exercise, and Its Relationship to Carbohydrate Metabolism , Biochem J 33:1425-1431, 1939;.
5 +
Findley, T., Jr.:  The Excretion of Endogenous 'Creatinine' by the Human Kidney , Amer J Physiol 123:260-265, 1938;.
6 +
Brod, J., and Sirota, J.H.:  The Renal Clearance of Endogenous 'Creatinine' in Man , J Clin Invest 27:645-654, 1948;.
7 +
Steinitz, K., and Türkand, H.:  The Determination of Glomerular Filtration by the Endogenous Creatinine Clearance , J Clin Invest 19:285-298, 1940;.
8 +
Bonsnes, R.W., and Taussky, H.H.:  On the Colorimetric Determination of Creatinine by the Jaffe Reaction , J Biol Chem 158:581-591, 1945;.
9 +
Hare, R.S.:  Endogenous Creatinine in Serum and Urine , Proc Soc Exp Biol Med 74:148-151, 1950;.
10 +
Polar, E., and Metcoff, J.:  'True' Creatinine Chromogen Determination in Serum and Urine by Semi-Automated Analysis , Clin Chem 11:763-770, 1965;.
11 +
Mattar, G., et al:  Measurement of Glomerular Filtration Rate in Children With Kidney Disease , J Clin Invest 31:938-946, 1952;.
12 +
Dodge, W.F., and Daeschner, C.W.:  Factors Influencing the Short-Term Measurement of Glomerular Filtration Rate by Endogenous Creatinine Clearance , Clin Res 8:62, 1960;.
13 +
Ikkos, D., and Strom, L.:  A Comparison of the Endogenous Creatinine and Inulin Clearances in Children , Acta Paediat (Stockholm) 44:426-434, 1955;.
14 +
Berlyne, G.M., et al:  Endogenous-Creatinine Clearance and Glomerular-Filtration Rate , Lancet 2:874-876, 1964;.
15 +
Vere, D.W., and Walduck, A.:  Endogenous-Creatinine Clearance and Glomerular-Filtration Rate , Lancet 2:1299, 1964;.
16 +
Berlyne, G.M.:  Endogenous Creatinine Clearance and the Glomerular Filtration Rate , Amer Heart J 70:143-145, 1965;.
17 +
Hawk, P.B.; Oser, B.L.; and Summerson, W.H.: Practical Physiological Chemistry , ed 13, New York: McGraw-Hill Book Co., Inc. 1954;, p 900.
18 +
Folin, O., and Morris, J.L.:  On the Determination of Creatinine and Creatine in Urine , J Biol Chem 17:469-473, 1914;.
19 +
Schreiner, G.E:  Determination of Inulin by Means of Resorcinol , Proc Soc Exp Biol Med 74:117-120, 1950;.
20 +
Sirota, J.H.; Baldwin, D.S.; and Villarreal, H.:  Diurnal Variations of Renal Function in Man , J Clin Invest 29:187-192, 1950;.
21 +
Best, W.R.; Kuhl, W.H., Jr.; and Friedemann, T.E.:  Diurnal Trend and Variation of Urinary Creatinine Excretion , Fed Proc 11:188, 1952;.
22 +
Shannon, J.A.:  The Renal Excretion of Creatinine in Man , J Clin Invest 14:403-410, 1935;.
23 +
Enger, E., and Blegen, E.M.:  The Relationship Between Endogenous Creatinine Clearance and Serum Creatinine in Renal Failure , Scand J Clin Lab Invest 16:273-280, 1964;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems