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Thrombocytopenic Purpura and Pneumonia Following Measles Vaccination

Daniel J. Wilhelm, MD; Roland D. Paegle, MD
Am J Dis Child. 1967;113(5):534-537. doi:10.1001/archpedi.1967.02090200066004.
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WITH the development of a safe, effective measles vaccine, it has recently become an accepted and recommended procedure to immunize susceptible children against this disease which can cause significant mortality and morbidity. The live, attenuated measles virus vaccines, derived from the Edmonston B strain and the Schwarz strain, are the vaccines of choice for routine immunization.1,2 These vaccines require only one injection and seemingly confer a lifetime of immunity.3 No serious reaction from the use of these vaccines has been reported, but convulsions secondary to vaccine-induced fever may occur.4 This report describes two unusual complications which followed vaccination with live, attenuated measles virus.

Report of Cases  Case 1.—A 12-month-old white girl received a subcutaneous, live virus attenuated measles vaccine injection (Edmonston strain) with γ-globulin (0.01 cc/lb). Seven days later she became fussy and developed a fever. On the eighth postvaccination day, a hive-like rash developed on the

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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