IT IS WELL recognized that patients with sickle cell disease have hyposthenuria.1 This hyposthenuria results in the excretion of increased volumes of urine during a 24-hour period. It has been our impression that this polyuria results in an increased incidence of enuresis among children with sickle cell anemia. This report deals with a survey that confirms that impression.
Materials and Methods
The parents of all patients, or former patients, in the pediatric hematology clinics of the Hospital of the University of Pennsylvania or the Philadelphia General Hospital with a diagnosis of sickle cell anemia (SS) that had been confirmed by hemoglobin electrophoresis were interviewed either in the clinic or by telephone.During the same period of time 50 Negro children ranging in age from 4 to 12 years were similarly interviewed. These children were selected at random from the pediatric medical clinics.
Twenty-nine children with sickle cell anemia