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March 1967, Vol 113, No. 3 >
Article | March 1967

Blood Leukocyte Response to Live Measles Vaccine FREE

F. L. Black, PhD; S. R. Sheridan, MD
[+] Author Affiliations

Received for publication June 8, 1966.

Reprint requests to 333 Cedar St, New Haven, Conn 06511 (Dr. Black).


Am J Dis Child. 1967;113(3):301-304. doi:10.1001/archpedi.1967.02090180061002.
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LEUKOPENIA is a characteristic sign of many viral infections and the blood picture in measles is typical of this effect. The leukopenia of natural measles has been the subject of many publications,1-3 but the pattern of changes has been blurred by the absence of precise information on the time and amount of infecting virus and confounded with changes associated with response to secondary bacterial infections. In general, however, it has been shown that the numbers of all major cell types decrease during the prodromal period. Lymphocytes recover somewhat sooner than neutrophils, giving rise to a relative lymphocytosis during the period of rash, the time at which most studies have been made. There have been various and conflicting reports of periods of absolute leukocytosis, but most writers suggest that a slight leukocytosis occurs during the incubation period.

The clinical reaction elicited by live Edmonston measles vaccine mimics a mild case

REFERENCES

1 +
Benjamin, B., and Ward, S.M.:  Leukocyte Response to Measles , Amer J Dis Child 44:921, 1932;.
2 +
Bjorn-Hansen, H.:  Leukozyten-Untersuchungen bei den Masern , Acta Paediat Scand 14 ( (suppl 1) ):1-180, 1932;.
3 +
Bartolozzi, G.; Borgheresi, S.; and Minucci, M.:  Il comportamento degli eosinofili nel morbillo , Riv Clin Pediat 53:82, 1954;.
4 +
Silber, R.H.; Busch, R.D.; and Oslapas, R.:  Practical Procedure for Estimation of Corticosterone or Hydrocortisone , Clin Chem 4:278, 1958;.
5 +
Berg, R.B., and Rosenthal, M.S.:  Propagation of Measles Virus in Suspension of Human and Monkey Leukocytes , Proc Soc Exp Biol Med 106:581, 1961;.
6 +
Papp, K.:  Fixation du virus morbilleux aux leucocytes du sang des las periode d'incubation de la maladie , Bull Acad Nat Med 117:46, 1937;.
7 +
McCrumb, F.R., et al:  Studies With Live Attenuated Measles-Virus Vaccine: I. Clinical and Immunological Responses in Institutionalized Childuced Infectious Hepatitis , Amer J Med Sci
8 +
Havens, W.P., and Marck, R.E.:  The Leukocyte Response of Patients With Experimentally Induced Infectious Hepatitis , Amer J Med Sci 212:129, 1946;.

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References

1 +
Benjamin, B., and Ward, S.M.:  Leukocyte Response to Measles , Amer J Dis Child 44:921, 1932;.
2 +
Bjorn-Hansen, H.:  Leukozyten-Untersuchungen bei den Masern , Acta Paediat Scand 14 ( (suppl 1) ):1-180, 1932;.
3 +
Bartolozzi, G.; Borgheresi, S.; and Minucci, M.:  Il comportamento degli eosinofili nel morbillo , Riv Clin Pediat 53:82, 1954;.
4 +
Silber, R.H.; Busch, R.D.; and Oslapas, R.:  Practical Procedure for Estimation of Corticosterone or Hydrocortisone , Clin Chem 4:278, 1958;.
5 +
Berg, R.B., and Rosenthal, M.S.:  Propagation of Measles Virus in Suspension of Human and Monkey Leukocytes , Proc Soc Exp Biol Med 106:581, 1961;.
6 +
Papp, K.:  Fixation du virus morbilleux aux leucocytes du sang des las periode d'incubation de la maladie , Bull Acad Nat Med 117:46, 1937;.
7 +
McCrumb, F.R., et al:  Studies With Live Attenuated Measles-Virus Vaccine: I. Clinical and Immunological Responses in Institutionalized Childuced Infectious Hepatitis , Amer J Med Sci
8 +
Havens, W.P., and Marck, R.E.:  The Leukocyte Response of Patients With Experimentally Induced Infectious Hepatitis , Amer J Med Sci 212:129, 1946;.

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