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Dietary Treatment of Homocystinuria

Am J Dis Child. 1967;113(1):98-100. doi:10.1001/archpedi.1967.02090160148022.
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WE WERE fortunate while examining two older children with homocystinuria to learn that their mother was pregnant once again. We were able to obtain cord blood and urine from the baby (patient 1) on the first day; a further urine collection was taken on the third day; and plasma was obtained on the fourth day of life. A very small amount of homocystine was detected in the urine after 56 hours and after 72 hours the plasma methionine had risen from 0.8 to 1.5 mg/100 ml, and the homocystine was 0.4 mg/100 ml. We did not initiate dietary treatment at this stage, and on the ninth day of life life when the plasma methionine level was 26.8 mg/100 ml and the homocystine 1.2 mg/100 ml, dietary treatment was started on patient 1. This is a similar story to that described by Perry.1 This treatment was similar to the diet


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