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January 1967, Vol 113, No. 1 >
Article | January 1967

Hydroxykynureninuria FREE

G. M. KOMROWER, MB, FRCP; ROLAND WESTALL, DSc
[+] Author Affiliations

Received for publication Sept 19, 1966.

Read before the Symposium on Treatment of Amino Acid Disorders, Children's Memorial Hospital, Chicago, Sept 3-4, 1966.

Reprint requests to Royal Manchester Children's Hospital, Manchester, England (Dr. Komrower).


Am J Dis Child. 1967;113(1):77-80. doi:10.1001/archpedi.1967.02090160127016.
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HYDROXYKYNURENINURIA is a disorder of tryptophan metabolism in respect of its conversion to nicotinic acid in which the individual excretes large amounts of xanthurenic acid, kynurenine, and 3-hydroxykynurenine on a normal diet, without the stress of a tryptophan load.

A girl, now 14 years of age, came to us in 1952 when she was 3 weeks old. Diarrhea and ulceration of the mouth occurred within ten days of birth, the diarrhea progressing to an entero-colitis with blood and mucus. Hemolytic anemia, apparently of the acquired type, occurred at 3 weeks of age; Coombs' test was negative. The general condition of the child deteriorated after a blood transfusion; a marked hepatosplenomegaly and jaundice developed which finally disappeared after several weeks. This was not explained; the blood had been carefully cross-matched. High fever and diarrhea persisted intermittently until 5 months of age.

Dwarf stature was noted soon after birth and the child

REFERENCES

1 +
Dalgleish, C.E.: "Biosynthesis of Niacin and Pyridoxine," in Symposium XI: Vitamin Metabolism, Fourth International Congress of Vienna, 1960.
2 +
Dalgleish, C.E.; Knox, W.E.; and Neuberger, A.:  Intermediary Metabolism of Tryptophan , Nature 168:20, 1951;.
3 +
Gregory, I.:  Role of Nicotinic Acid (Niacin) in Mental Health and Disease , J Ment Sci 101:83, 1955;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Dalgleish, C.E.: "Biosynthesis of Niacin and Pyridoxine," in Symposium XI: Vitamin Metabolism, Fourth International Congress of Vienna, 1960.
2 +
Dalgleish, C.E.; Knox, W.E.; and Neuberger, A.:  Intermediary Metabolism of Tryptophan , Nature 168:20, 1951;.
3 +
Gregory, I.:  Role of Nicotinic Acid (Niacin) in Mental Health and Disease , J Ment Sci 101:83, 1955;.

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