A PROGRAM for treatment of children with phenylketonuria (PKU) has been in progress in Cincinnati since 1956. Experience within a closely knit interdisciplinary metabolic team has permitted us to form a comprehensive treatment program which illustrates the intense, constant, well-supervised, and well-monitored care needed for this chronic metabolic disease. In spite of the time and attention devoted to PKU over the past decade the treatment should still be considered experimental in nature. Final evaluation of dietary therapy must wait until it is determined if treated patients can achieve an independent economic and social existence. Preliminary evaluations of results of treatment are presented as a progress report at the present time.
Out treatment program consists of three mutually dependent areas: biochemical control, dietary management, and close medical supervision. The members of the treatment group as well as the patient's family must be prepared to devote a great deal of time and