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Galactitol in the Tissues of a Galactosemic Child

RONALD QUAN-MA, PhD; HENRY J. WELLS, PhD; WILLIAM W. WELLS, PhD; FRANK E. SHERMAN, MD; THOMAS J. EGAN, MD
Am J Dis Child. 1966;112(5):477-478. doi:10.1001/archpedi.1966.02090140149018.
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GALACTITOL has recently been isolated from the urine1 and brain2 of galactosemia patients. Subsequently the conversion of orally administered galactose- 1-C14 into galactitol-1-C14 by a 17-year-old male galactosemia patient was demonstrated.3 In order to account for the relatively slow excretion of administered radioactivity as galactitol-C14 it was suggested that there had either been deposition of galactitol in tissues of the body, or that the administered galactose-C14 had been incorporated into galactose-containing compounds. This hypothesis was further supported by the finding of galactitol in a variety of tissues in a rat fed large amounts of galactose.4 We now wish to report the galactitol, glucose, free, and phosphatide-bound myo-inositol content of body tissue from 17 areas of an infant presumed to be galactosemic.

Material and Methods  The patient studied was a 23-day-old male infant who was jaundiced on the third day of life.

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