Those to whom the first edition, twice reprinted, of Hsia's sequel to Garrod has become a sort of vade mecum, will be delighted with the second. The core of the book has been enlarged by almost 100 pages, chiefly through the device of relegating to Part 2, a complete second volume, the laboratory manual which formed the appendix of the first edition.
This conservation of space, the development of scientific knowledge of the subject and, doubtless, the author's growth in perspicacity have resulted in the production of a more comprehensive and certainly a more mature monograph. The introductory section on basic genetics has been amplified by a discussion of cytogenetics and biochemical genetics. There is a fundamental chapter on "Biochemical Variations in Normal Human Beings," providing a focus which will enable the newcomer to view inborn errors in proper perspective. The chapters on the "Hemoglobinopathies" and on "Enzyme Defects" emphasize