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Am J Dis Child. 1966;112(2):167. doi:10.1001/archpedi.1966.02090110110020.
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To the Editor: In response to the letter from Dr. Borenstine I should like to state that the purpose of my own article was simply to record the fact that an injection of particulate penicillin had been followed by a transverse myelitis. This incident occurred 24 hours before the child entered our hospital and the suggestion of using lidocaine (Xylocaine) was considered along with a great many others, all of which were abandoned because the length of time precluded the possibility that transient spasm and subsequent clotting could be treated by any reasonable method at this time. Particularly, it was felt that almost anything which might be done would risk making the matter worse.

The exact mechanism was incapable of proof. I believe that the similarity to the injection of anesthetic agents into arteries, the very peculiar arterial gangrene and extremity paralysis which followed a British experience in which nikethamide


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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