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Am J Dis Child. 1966;112(2):166-167. doi:10.1001/archpedi.1966.02090110110019.
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To the Editor: I have just finished reading an article in the Journal, entitled "Accidental Intra-Arterial Injection of Penicillin" by John A. Knowles, MD, (Amer J Dis Child 111:552-556, 1966). In the body of this article it is postulated that a dose of penicillin was accidently injected into an artery in the gluteal region of a baby causing tissue slough and scarring. In view of the known great irritability of arteriolar musculature to both tactile and chemical stimulation, I would like to suggest that it is almost impossible to inject material intra-arterially except by directly exposing the artery and inserting an instrument into the lumen under direct vision.

Three years ago we had a similar experience following the injection of penicillin into the antero-lateral aspect of the thigh of a 7-year-old boy. We subsequently realized that the pathological findings in this incident could have been caused purely by arterial spasm


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