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July 1966, Vol 112, No. 1 >
Article | July 1966

Changes in the Pattern of Neonatal Septicemia and Meningitis FREE

GEORGE H. McCRACKEN, MD; HENRY R. SHINEFIELD, MD
[+] Author Affiliations

Received for publication April 1, 1966.

Reprint requests to Kaiser Foundation Hospital, 2425 Geary Blvd, San Francisco, Calif 94115 (Dr. Shinefield).


Am J Dis Child. 1966;112(1):33-39. doi:10.1001/archpedi.1966.02090100069006.
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References
Comments

THIS STUDY was designed to review an 11-year experience with neonatal septicemia and meningitis at the New York Hospital. Particular attention is focused on the changing pattern of infection and etiological agents, the predisposing conditions to neonatal infection, and problems in diagnosis and therapy.

Material  The material for this study included all cases indexed by the New York Hospital record department as neonatal septicemia or meningitis. Only infants 30 days old or younger were considered. The 115 cases indexed between July 1953 and September 1964 included: (1) 31 infants suspected on clinical observation to have septicemia but without a confirmatory positive blood culture, (2) 68 cases proved by blood culture or spinal fluid culture or both; cultures were positive prior to death in those infants that died, (3) three infants who were not cultured prior to death, but who showed at autopsy bacteriologic and histologic evidence of septicemia, and (4)

REFERENCES

1 +
Annual Reports of the Society of the Lying-In Hospital of the City of New York, 1953-64.
2 +
Burgert, W., and Hagstrom, J.W.C.:  Vibrio Fetus Meningoencephalitis , Arch Neurol 10:196, 1964;.
3 +
Groover, R.V.; Sutherland, J.M.; and Landing, B.H.:  Purulent Meningitis of Newborn Infants , New Eng J Med 264:1115, 1961;.
4 +
Haggarty, R.J., and Ziai, M.:  Acute Bacterial Meningitis , Advances Pediat 13:129, 1964;.
5 +
Hoffman, M.A., and Finberg, L.:  Pseudomonas Infections in Infants Associated With High-Humidity Environments , J Pediat 46:626, 1955;.
6 +
George, R.M.; Cochran, C.P.; and Wheeler, W.E.:  Epidemic Meningitis of the Newborn Caused by Flavobacteria , Amer J Dis Child 101:296, 1961;.
7 +
Blanc, W.A.:  Pathways of Fetal and Early Neonatal Infection , J Pediat 59:473, 1961;.
8 +
Buetow, K.C.; Klein, S.W.; and Lane, R.B.:  Septicemia in Premature Infants , Amer J Dis Child 110:29, 1965;.
9 +
Fink, C.W., et al:  The Formation of Macroglobulin Antibodies: II. Studies on Neonatal Infants and Older Children , J Clin Invest 41:1422, 1962;.
10 +
Smith, R.T., and Eitzman, D.V.:  The Develop- ment of the Immune Response , Pediatrics 65:163, 1964;.
11 +
Blanc, W.A.:  Role of the Amniotic Infection Syndrome in Perinatal Pathology , Bull Sloane Hosp Wom 3:79, 1957;.
12 +
Wilson, M.G., and Armstrong, D.H.:  Inflammation of the Umbilical Cord and Neonatal Illness , Amer J Obstet Gynec 90:843, 1964;.
13 +
Benirschke, K., and Clifford, S.:  Intrauterine Bacterial Infection of the Newborn Infant: Frozen Sections of the Cord as an Aid to Early Detection , J Pediat 54:11, 1959;.
14 +
Dunham, E.C.:  Septicemia in the Newborn , Amer J Dis Child 45:229, 1933;.
15 +
Waddell, W.W.; Balsley, R.E.; and Grossman, W.:  Positive Blood Cultures in Newborn Infants , J Pediat 38:426, 1948;.
16 +
Pryles, C.V., et al:  A Controlled Study of the Influence on the Newborn of Prolonged Premature Rupture of the Amniotic Membranes and/or Infection in the Mother , Pediatrics 31:608, 1963;.
17 +
Eitzman, D.V., and Smith, R.T.:  The Significance of Blood Cultures in the Newborn Period , Amer J Dis Child 94:601, 1957;.

Figures

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Annual Reports of the Society of the Lying-In Hospital of the City of New York, 1953-64.
2 +
Burgert, W., and Hagstrom, J.W.C.:  Vibrio Fetus Meningoencephalitis , Arch Neurol 10:196, 1964;.
3 +
Groover, R.V.; Sutherland, J.M.; and Landing, B.H.:  Purulent Meningitis of Newborn Infants , New Eng J Med 264:1115, 1961;.
4 +
Haggarty, R.J., and Ziai, M.:  Acute Bacterial Meningitis , Advances Pediat 13:129, 1964;.
5 +
Hoffman, M.A., and Finberg, L.:  Pseudomonas Infections in Infants Associated With High-Humidity Environments , J Pediat 46:626, 1955;.
6 +
George, R.M.; Cochran, C.P.; and Wheeler, W.E.:  Epidemic Meningitis of the Newborn Caused by Flavobacteria , Amer J Dis Child 101:296, 1961;.
7 +
Blanc, W.A.:  Pathways of Fetal and Early Neonatal Infection , J Pediat 59:473, 1961;.
8 +
Buetow, K.C.; Klein, S.W.; and Lane, R.B.:  Septicemia in Premature Infants , Amer J Dis Child 110:29, 1965;.
9 +
Fink, C.W., et al:  The Formation of Macroglobulin Antibodies: II. Studies on Neonatal Infants and Older Children , J Clin Invest 41:1422, 1962;.
10 +
Smith, R.T., and Eitzman, D.V.:  The Develop- ment of the Immune Response , Pediatrics 65:163, 1964;.
11 +
Blanc, W.A.:  Role of the Amniotic Infection Syndrome in Perinatal Pathology , Bull Sloane Hosp Wom 3:79, 1957;.
12 +
Wilson, M.G., and Armstrong, D.H.:  Inflammation of the Umbilical Cord and Neonatal Illness , Amer J Obstet Gynec 90:843, 1964;.
13 +
Benirschke, K., and Clifford, S.:  Intrauterine Bacterial Infection of the Newborn Infant: Frozen Sections of the Cord as an Aid to Early Detection , J Pediat 54:11, 1959;.
14 +
Dunham, E.C.:  Septicemia in the Newborn , Amer J Dis Child 45:229, 1933;.
15 +
Waddell, W.W.; Balsley, R.E.; and Grossman, W.:  Positive Blood Cultures in Newborn Infants , J Pediat 38:426, 1948;.
16 +
Pryles, C.V., et al:  A Controlled Study of the Influence on the Newborn of Prolonged Premature Rupture of the Amniotic Membranes and/or Infection in the Mother , Pediatrics 31:608, 1963;.
17 +
Eitzman, D.V., and Smith, R.T.:  The Significance of Blood Cultures in the Newborn Period , Amer J Dis Child 94:601, 1957;.

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