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Neonatal Exophthalmos With Maternal Thyrotoxicosis

MALCOLM M. MARTIN, MD, MRCP; RICHARD N. MATUS, MD
Am J Dis Child. 1966;111(5):545-547. doi:10.1001/archpedi.1966.02090080123013.
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NEONATAL exophthalmos with or without hyperthyroidism is a rare complication of maternal Graves's disease. Sclare1 collected 12 cases of thyrotoxicosis of the newborn published up to 1957. In the past seven years, nine more cases have been added.2-6 Of the 21 infants reported to date, clinical details are available in 17. The manifestations of hyperthyroidism, though variable in severity, were essentially similar to those seen in the older child and adult. Eleven infants appeared thyrotoxic at birth, four became toxic within the first week, one within two weeks, and one as late as six weeks after delivery. The delay in the appearance of hyperthyroidism was related to antithyroid therapy. When the mother was treated with antithyroid durgs up to the time of delivery, the baby was euthyroid at birth and thyrotoxicosis did not become manifest until the effect of the drug had worn off. Thirteen of the 17 infants

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