Neonatal Exophthalmos With Maternal Thyrotoxicosis FREE

MALCOLM M. MARTIN, MD, MRCP; RICHARD N. MATUS, MD

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Received for publication Dec 10, 1965.

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Am J Dis Child. 1966;111(5):545-547. doi:10.1001/archpedi.1966.02090080123013.

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ABSTRACT

ABSTRACT | REFERENCES

NEONATAL exophthalmos with or without hyperthyroidism is a rare complication of maternal Graves's disease. Sclare¹ collected 12 cases of thyrotoxicosis of the newborn published up to 1957. In the past seven years, nine more cases have been added.^2-6 Of the 21 infants reported to date, clinical details are available in 17. The manifestations of hyperthyroidism, though variable in severity, were essentially similar to those seen in the older child and adult. Eleven infants appeared thyrotoxic at birth, four became toxic within the first week, one within two weeks, and one as late as six weeks after delivery. The delay in the appearance of hyperthyroidism was related to antithyroid therapy. When the mother was treated with antithyroid durgs up to the time of delivery, the baby was euthyroid at birth and thyrotoxicosis did not become manifest until the effect of the drug had worn off. Thirteen of the 17 infants

REFERENCES

ABSTRACT | REFERENCES

Sclare, G.: Congenital Hyperthyroidism , Biol Neonat 2:132, 1960;.

Javett, S.N., et al: Neonatal Thyrotoxicosis , Pediatrics 24:65, 1959;.

Paatela, M.: Neonatal Thyrotoxicosis , Ann Paediat Fenn 6:309, 1960;.

Rosenberg, D.; Grand, M.J.H.; and Silbert, D.: Neonatal Hyperthyroidism , New Eng J Med 268: 292, 1963;.

Adams, D.D.; Lord, J.M.; and Stevely, H.A.A.: Congenital Thyrotoxicosis , Lancet 2:497, 1964;.

McKenzie, J.M.: Neonatal Graves' Disease , J Clin Endocr 24:660, 1964;.

Keynes, G.: Obstetrics and Gynaecology in Relation to Thyrotoxicosis and Myasthenia Gravis , J Obstet Gynaec Brit Comm 59:173, 1952;.

Van Middlesworth, L.: Radioactive Iodine Uptake of Normal Infants , Amer J Dis Child 88:439, 1954;.

Danowski, T.S., et al: Protein-Bound Iodine in Infants From Birth to One Year of Age , Pediatrics 7:240, 1951;.

Dobyns, B.M., and Wilson, L.A.: Exophthalmos Producing Substance in Serum of Patients Suffering From Progressive Exophthalmos , J Clin Endocr 14: 1393, 1954;.

Adams, D.D., and Purvis, H.D.: Abnormal Responses in the Assay of Thyrotrophin , Proc Univ Otago Med Sch 34:11, 1956;.

McKenzie, J.M.: Studies on the Thyroid Activator of Hyperthyroidism , J Clin Endocr 21:635, 1961;.

Pimstone, B.L.; Hoffenberg, R.; and Black, E.: Parallel Assays of Thyrotrophin, Long-Acting Thyroid Stimulator and Exophthalmos-Producing Substance in Some Endocrine Disorders , J Clin Endocr 23:336, 1963;.

Bottari, P.M., and Donovan, B.T.: A Sensitive in Vitro Technique for the Assay of Thyrotrophic Hormone , J Physiol 140:36P, 1958;.

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