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Congenital Nephrotic Syndrome With Interstitial Nephritis

WARREN E. GRUPE, MD; FRANCIS E. CUPPAGE, MD; WALTER HEYMANN, MD
Am J Dis Child. 1966;111(5):482-489. doi:10.1001/archpedi.1966.02090080060003.
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THE CONGENITAL nephrotic syndrome is probably a heterologous group from which microcystic disease and membranous glomerulonephritis have been separated as histologic entities. This syndrome has also been reported in association with cytomegalic inclusion disease,1 renal vein thrombosis,2 and congenital syphilis.3 A heredofamilial form is suggested by a number of reports of this syndrome in two or more siblings.1,4-9 Pyelonephritis in association with the nephrotic syndrome is not well established, particularly in the early phases of the disease, and is not recognized as an etiologic factor.10,11 This report describes the association of chronic interstitial nephritis with the nephrotic syndrome in an infant with abnormal external genitalia.

Report of a Case  A male infant, weighing 8 lb 7 oz (3,832 gm), was born following a 41-week uncomplicated gestation. His 18-year-old, gravida 1, para 1, mother was in good health and had no known infection or renal disease

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