Inhalational vs Oral Steroid Therapy in Childhood Asthma FREE

LILLIAN P. KRAVIS, MD; HAROLD I. LECKS, MD

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Received for publication Sept 2, 1965.

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Am J Dis Child. 1966;111(4):343-352. doi:10.1001/archpedi.1966.02090070041002.

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ABSTRACT

ABSTRACT | REFERENCES

PEDIATRIC allergists, numbering, as they invariably do, among their patients a small core of chronically ill, steroid-dependent asthmatic youngsters, have long shown an interest in inhalational steroid therapy, particularly since the adverse effects of long-term oral steroid usage became known. Their hope was that direct application of corticosteroids to the bronchi and subbronchial airways might result in a marked reduction in steroid requirements for this group of patients and, at the same time, might keep systemic absorption to such minimal levels that adrenocortical suppression would not occur. Ultimate weaning off of steroids might thus be facilitated. When a compact aerosol eventually was devised which contained the highly water-soluble dexamethasone-sodium-21-phosphate in a small-particled, relatively tasteless form, it was promptly put to clinical trial in centers in this country and elsewhere where young and old asthmatic patients were under treatment. The purpose of this paper is to summarize the published results of

REFERENCES

ABSTRACT | REFERENCES

Snider, G.L., et al: Effect of Dexamethasone Aerosol on Airway Obstruction in Bronchial Asthma , Dis Chest 44:408, 1963;.

Toogood, J.F., and Lefcoe, N.M.: Dexamethasone Aerosol for the Treatment of "Steroid Dependent" Chronic Bronchial Asthmatic Patients , J Allerg 36:321, 1965;.

Seigel, S.C., et al: Effect of Dexamethasone Aerosols in Asthmatic Children , Pediatrics 33:245, 1964;.

Dennis, M., and Itkin, I.H.: Effectiveness and Complications of Aerosol Dexamethasone Phosphate in Severe Asthma , J Allerg 35:70, 1964;.

Bickerman, H.A., and Itkin, S.E.: Aerosol Steroid Therapy and Chronic Bronchial Asthma , JAMA 184:533, 1963;.

Arbesman, C.E.; Bonstein, H.S.; and Reisman, R.E.: Dexamethasone Aerosol Treatment for Bronchial Asthma , J Allerg 34:345, 1963;.

Crepea, S.B.: Inhalation of Dexamethasone by Mouth for Asthma , J Allerg 34:119, 1963;.

Fisch, B.R., and Grater, W.C.: Dexamethasone Aerosol in Respiratory Tract Disease , J New Drugs 2:298, 1962;.

Brown, H.M.: Aerosol Steroids in Bronchial Asthma , Lancet 2:147, 1963;.

Liddle, G.W.: Tests of Pituitary-Adrenal Suppressibility in the Diagnosis of Cushing's Syndrome , J Clin Endocr 20:1539, 1960;.

Linder, W.R.: Adrenal Suppression by Aerosol Steroid Inhalation , Arch Intern Med 113: 655, 1964;.

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