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March 1966, Vol 111, No. 3 >
Article | March 1966

Parathion Poisoning in a Young Infant FREE

ROBERT W. MACKEY, MD
[+] Author Affiliations

Received for publication Sept 15, 1965.

Reprint requests to 1430 Tulane Ave, New Orleans 70112. After June 1 Dr. Mackey's address will be Doctor's Building, 21st and Lewis, Tulsa, Okla.


Am J Dis Child. 1966;111(3):321-323. doi:10.1001/archpedi.1966.02090060131020.
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References
Comments

DURING World War II, it was found that parathion (O-O-diethyl O-p-nitrophenyl phosphothionate), in spite of its biological ability to produce respiratory paralysis, had neither the volatility, or solubility required of a war gas.1 This low volatility and solubility (together with its low cost) has popularized this substance as an insecticide, since the essential enzyme it interferes with is common to all animals including insects.

Toddlers have been known to ingest this poison and young children can readily absorb toxic amounts through the skin of their hands and feet. Numerous accidental poisonings have occurred as a result of skin contact, inhalation, or ingestion,3-8 often in children old enough to be ambulatory or to feed themselves. Toivonen,9 in 1951, commented on the increasing use of parathion as an agent in suicides. Seifert,10 reported on infanticide of a 9-week-old-baby who was given two or three drops of

REFERENCES

1 +
Hamblin, D.O., and Golz, H.H.:  Parathion Poisoning: A Brief Review , Industr Med Surg 24:65-72, 1955;.
2 +
Augustinsson, K.B.: In Methods of Biochemical Analysis , D. Glick (ed.), New York: Interscience Publishers, 1957;, vol 5, p 1.
3 +
Burgsch, H.G.:  Recent Deaths From Parathion Intoxication in Massachusetts , New Eng J Med 261:870, 1959;.
4 +
Kanagaratnam, K.; Boon, W.H.; and Hoh, T.K.:  Parathion Poisoning From Contaminated Barley , Lancet 1: 538-542, 1960;.
5 +
Wishahi, A., et al:  Parathion Poisoning , Arch Pediat 75:387-396, 1958;.
6 +
Chamberlin, J.R., and Cooke. R.E.:  Organic Phosphate Insecticide Poisoning , Amer J Dis Child 85:164-172, 1953;.
7 +
Grob, D., and Johns, R.J.:  Use of Oximes in the Treatment of Intoxication by Anticholinesterase Compounds in Normal Subjects , Amer J Med 24:497-511, 1958;.
8 +
Prater, H.W.:  Organic Phosphate Insecticide Poisoning , Bull Tulane Univ Med Faculty 23(No. (3) ):175-185 (May) 1964;.
9 +
Toivonen, T.; Ohela, K.; and Kaipainen, W.J.:  Parathion Poisoning: Increasing Frequency in Finland , Lancet 2:175-176, 1959;.
10 +
Seifert, P.:  Parathion Poisoning , Arch Toxikol 15: 80, 1954;.
11 +
Vercruysse, A., and Deslypere, P.:  Acute Parathion Poisoning , J Forensic Med 2(No. (3) ):107-119 (July-Sept) 1964;.
12 +
Grob, D.; Garlick, W.L., and Harvy, A.M.:  The Toxic in Man of the Anticholinesterase Insecticide Parathion , Bull J Hopkins Hosp 87:106, 1950;.
13 +
Hamblin, D.O., and Marchand, J.F.:  Parathion Poisoning , Amer Practitioner 2:1, 1951;.
14 +
Kaplan, E.:  Studies of Red Cell Survival in Early Infancy , J Dis Child 98:603, 1959;.
15 +
Wilson, I.B., and Ginsburg, S.:  A Powerful Reactivator of Alkylphosphate-Inhibited Acetylcholinesterase , Biochem Biophys Acta 18:168-170, 1955;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Hamblin, D.O., and Golz, H.H.:  Parathion Poisoning: A Brief Review , Industr Med Surg 24:65-72, 1955;.
2 +
Augustinsson, K.B.: In Methods of Biochemical Analysis , D. Glick (ed.), New York: Interscience Publishers, 1957;, vol 5, p 1.
3 +
Burgsch, H.G.:  Recent Deaths From Parathion Intoxication in Massachusetts , New Eng J Med 261:870, 1959;.
4 +
Kanagaratnam, K.; Boon, W.H.; and Hoh, T.K.:  Parathion Poisoning From Contaminated Barley , Lancet 1: 538-542, 1960;.
5 +
Wishahi, A., et al:  Parathion Poisoning , Arch Pediat 75:387-396, 1958;.
6 +
Chamberlin, J.R., and Cooke. R.E.:  Organic Phosphate Insecticide Poisoning , Amer J Dis Child 85:164-172, 1953;.
7 +
Grob, D., and Johns, R.J.:  Use of Oximes in the Treatment of Intoxication by Anticholinesterase Compounds in Normal Subjects , Amer J Med 24:497-511, 1958;.
8 +
Prater, H.W.:  Organic Phosphate Insecticide Poisoning , Bull Tulane Univ Med Faculty 23(No. (3) ):175-185 (May) 1964;.
9 +
Toivonen, T.; Ohela, K.; and Kaipainen, W.J.:  Parathion Poisoning: Increasing Frequency in Finland , Lancet 2:175-176, 1959;.
10 +
Seifert, P.:  Parathion Poisoning , Arch Toxikol 15: 80, 1954;.
11 +
Vercruysse, A., and Deslypere, P.:  Acute Parathion Poisoning , J Forensic Med 2(No. (3) ):107-119 (July-Sept) 1964;.
12 +
Grob, D.; Garlick, W.L., and Harvy, A.M.:  The Toxic in Man of the Anticholinesterase Insecticide Parathion , Bull J Hopkins Hosp 87:106, 1950;.
13 +
Hamblin, D.O., and Marchand, J.F.:  Parathion Poisoning , Amer Practitioner 2:1, 1951;.
14 +
Kaplan, E.:  Studies of Red Cell Survival in Early Infancy , J Dis Child 98:603, 1959;.
15 +
Wilson, I.B., and Ginsburg, S.:  A Powerful Reactivator of Alkylphosphate-Inhibited Acetylcholinesterase , Biochem Biophys Acta 18:168-170, 1955;.

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