Neurologic Damage Associated With Phenothiazine FREE

IBRAHIM A. DABBOUS, MD; ABRAHAM B. BERGMAN, MD

Received for publication May 12, 1965.

Reprint requests to Children's Orthopedic Hospital and Medical Center, 4800 Sand Point Way NE, Seattle 98105 (Dr. Bergman).

Am J Dis Child. 1966;111(3):291-296. doi:10.1001/archpedi.1966.02090060101012.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

SINCE THE introduction of phenothiazines, reports have appeared in the medical literature concerning their neurologic side effects. These vary from simple "jitteriness" to the more alarming reactions of Parkinson's syndrome and of rigors simulating tetanus. The course and outcome are generally considered benign in spite of the alarming presenting symptoms which are "more of a shock to the doctor than a threat to the patient."¹

As far as can be determined from a review of the recent medical literature, irreversible neurologic damage following these reactions in the pediatric age group has not been reported.² The purpose of this paper is to describe a case with apparent permanent neurological sequelae associated with phenothiazine ingestion.

Report of a Case A 5-year-old white boy was admitted to Children's Orthopedic Hospital and Medical Center on Aug 8, 1963. One hour prior to admission he complained of sudden onset of pain and burning

REFERENCES

ABSTRACT | REFERENCES

O'Hara, V.S.: Extrapyramidal Reactions in Patients Receiving Prochlorperazine , New Eng J Med 259:826, 1958;.

Wiley, B.L.: Personal communication to the author, Smith Kline and French Laboratories, Philadelphia.

Vesell, E.S.: Urinary Test for a Metabolite of Prochlorperazine , New Eng J Med 260:1078, 1959;.

Cohen, S.: The Chemical Extrapyramidal Syndrome: Its Reduction With UK-738 , Med Exp 8:101, 1963;.

Ayd, F.J., Jr.: A Survey of Drug-Induced Extrapyramidal Reactions , JAMA 175:1054, 1961;.

Domino, E.F.: Human Pharmacology of Tranquillizing Drugs , Clin Pharmacol Ther 3:599, 1962;.

Marks, J.: Current Views on Psychotropic Drugs , New Zeal Med J 61:391, 1962;.

Hollister, L.E., and Kosek, J.C.: Sudden Death During Treatment With Phenothiazine Derivatives , JAMA 192:1035, 1965;.

Sarwer-Foner, G.J.: Recognition and Management of Drug-Induced Extrapyramidal Reactions and Paradoxical Behavioral Reactions in Psychiatry , Canad Med Assoc J 83:312, 1960;.

Brandrup, E.: Tetrabenacine Treatment in Persisting Dyskinesia Caused by Psychopharmaca , Amer J Psychiat 118:551, 1961;.

Druckman, R.; Seelinger, D.; Thulin, B.: Chronic Involuntary Movements Induced by Phenothiazines , J Nerv Ment Dis 135:69, 1962;.

Report from The Neurologic Actions of Phenothiazine Compounds , Philadelphia: Smith Kline and French Laboratories Publication, (October) 1959;.

Hollister, L.E.: Complications From the Use of Tranquillizing Drugs , New Eng J Med 257:170, 1957;.

Eckhardt, W.F., Jr.: Cervical Lingual Masticator Myoclonus—A Reaction to Prochlorperazine , Conn Med 25: 284, 1961;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal