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Kittens as Experimental Model for Study of Kernicterus

Am J Dis Child. 1966;111(2):161-165. doi:10.1001/archpedi.1966.02090050093006.
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IN AN EARLIER publication,1 a method was reported by which brain damage, similar to that of kernicteric infants, was produced in newborn kittens by intravenous injections of bilirubin. In subsequent work an attempt was made to develop a simple and reliable technique by which these animals could be used as an experimental tool for the further study of bilirubin toxicity in vivo. Such a method has been worked out and is presented in this communication.

Materials and Method  Newborn kittens in good health were used in this series of experiments. They received intravenous injections of bilirubin in a solution of bovine albumin. The solution was prepared according to the following formula.Crystalline bilirubin (Nutritional Biochemicals) 500 mg 0.75 N NaOH 5.0 ml Distilled water 5.0 ml Bovine albumin 30% (Armour) 5.0 ml 1M KH2PO4 2.75 mlIn this modification, we used double dilution of sodium hydroxide


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