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January 1966, Vol 111, No. 1 >
Article | January 1966

Leukocytosis During Steroid Therapy FREE

T. JACOB JOHN, MRCP(E), DCH
[+] Author Affiliations

Received for publication July 12, 1965.

Reprint requests to Department of Pediatrics, University of Colorado Medical Center, 4200 E Ninth Ave, Denver 80220.


Am J Dis Child. 1966;111(1):68-70. doi:10.1001/archpedi.1966.02090040104012.
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ADRENOCORTICAL steroids are known to cause eosinophenia and lymphopenia, but information as to their effects on other white blood cells is limited.1,2 Even though moderate neutrophilic leukocytosis has been reported in adults receiving steroids, there is no information regarding their effects in children, and no data available on changes in monocyte counts.1-3 This paper reports the effects of large doses of steroids on the circulating white blood cells in children.

Materials and Methods  Ten patients suffering from nonhematological diseases, who received large doses of prednisone, prednisolone, or triamcinolone (hereafter referred to as steroids), were studied by serial white cell counts. None of the patients revealed any evidence of clinical infection during the period of study. Their description, diagnoses, and dosage of steroids are given in the Table. Five children were given steroids in large doses for two weeks, two children for three to six weeks, and three children

REFERENCES

1 +
Sprague, R.G., et al:  Observations on the Physiologic Effects of Cortisone and ACTH in Man , Arch Inter Med 85:199, 1950;.
2 +
Wintrobe, M.M.: Clinical Hematology , Philadelphia: Lea & Febiger, 1961;.
3 +
Biorck, G.; Bottiger, L.E.; and Orinius, E.:  Leukocytosis During Corticosteroid Therapy , Acta Med Scand 176: 127, 1964;.
4 +
Finch, S.C., et al:  Hematologic Changes With ACTH and Cortisone Therapy of Rheumatoid Arthritis , Blood 6: 1034, 1951;.
5 +
Quittner, H., et al:  The Effect of Massive Doses of Cortisone on the Peripheral Blood and Bone Marrow of the Mouse , Blood 6:513, 1951;.
6 +
Herbert, P.H., and de Vries, J.A.:  The Administration of Adrenocorticotropic Hormone to Normal Human Subjects: The Effect of the Leucocytes in the Blood and on Circulating Antibody Levels , Endocrinology 44:259, 1949;.
7 +
Palmer, J.G.; Cartwright, G.E.; and Wintrobe, M.M.: "The Effects of ACTH and Cortisone on the Blood of Experimental Animals," in Proceedings of the Second Clinical ACTH Conference London: J. & A. Churchill, 1951, vol 1, p 438.
8 +
Hills, A.G.; Forsham, P.H.; and Finch, C.A.:  Changes in Circulating Leukocytes Induced by the Administration of Pituitary Adrenocorticotropic Hormone (ACTH) in Man , Blood 3:755, 1948;.
9 +
Keele, C.A., and Neil, E.: Samson Wright's Applied Physiology , New York: Oxford University Press, Inc., 1963;, p 95.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Sprague, R.G., et al:  Observations on the Physiologic Effects of Cortisone and ACTH in Man , Arch Inter Med 85:199, 1950;.
2 +
Wintrobe, M.M.: Clinical Hematology , Philadelphia: Lea & Febiger, 1961;.
3 +
Biorck, G.; Bottiger, L.E.; and Orinius, E.:  Leukocytosis During Corticosteroid Therapy , Acta Med Scand 176: 127, 1964;.
4 +
Finch, S.C., et al:  Hematologic Changes With ACTH and Cortisone Therapy of Rheumatoid Arthritis , Blood 6: 1034, 1951;.
5 +
Quittner, H., et al:  The Effect of Massive Doses of Cortisone on the Peripheral Blood and Bone Marrow of the Mouse , Blood 6:513, 1951;.
6 +
Herbert, P.H., and de Vries, J.A.:  The Administration of Adrenocorticotropic Hormone to Normal Human Subjects: The Effect of the Leucocytes in the Blood and on Circulating Antibody Levels , Endocrinology 44:259, 1949;.
7 +
Palmer, J.G.; Cartwright, G.E.; and Wintrobe, M.M.: "The Effects of ACTH and Cortisone on the Blood of Experimental Animals," in Proceedings of the Second Clinical ACTH Conference London: J. & A. Churchill, 1951, vol 1, p 438.
8 +
Hills, A.G.; Forsham, P.H.; and Finch, C.A.:  Changes in Circulating Leukocytes Induced by the Administration of Pituitary Adrenocorticotropic Hormone (ACTH) in Man , Blood 3:755, 1948;.
9 +
Keele, C.A., and Neil, E.: Samson Wright's Applied Physiology , New York: Oxford University Press, Inc., 1963;, p 95.

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