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Osseous Manifestations of the Congenital Rubella Syndrome

ARNOLD J. RUDOLPH, MB, BCh; EDWARD B. SINGLETON, MD; HARVEY S. ROSENBERG, MD; DON B. SINGER, MD; C. ALAN PHILLIPS, MD
Am J Dis Child. 1965;110(4):428-433. doi:10.1001/archpedi.1965.02090030448012.
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RUBELLA for many years was considered a mild disease of childhood. In 1941 Gregg reported the association of congenital cataracts with maternal rubella in the early months of pregnancy and since then the prenatal influence of maternal rubella in the first trimester has been well established.1

A widespread and virulent epidemic of rubella occurred in Houston in the spring and early summer of 1964. As an aftermath of this (from October 1964 to February 1965), involved infants were seen in the nursery, many with clinical manifestations not previously emphasized in relation to maternal rubella. These infants showed signs of a generalized disease, since they had marked growth retardation, purpuric lesions with thrombocytopenia, hepatosplenomegaly, central nervous system disease (full fontanelle, pleocytosis, and increased protein in the cerebrospinal fluid and abnormal electroencephalographic tracings), x-ray changes in the long bones and skull, and the congenital anomalies (cardiac defects, eye defects, and deafness)

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