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Acute Infectious Lymphocytosis

R. J. W. RYDER, MD, MRCPE, MRCPI, D Path, D Clin Path
Am J Dis Child. 1965;110(3):299-301. doi:10.1001/archpedi.1965.02090030313015.
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IN 1941 Reyersbach and Lenert described 16 cases of what they considered to be an atypical form of infectious mononucleosis occurring in a sanatorium for rheumatic children.10 None of the children had symptoms or physical manifestations of any kind, and the diagnosis was made on the basis of the blood picture, which showed a high leukocyte count and a striking increase in apparently normal lymphocytes. The results of Paul Bunnell heterophil agglutination reactions were uniformly negative. Later in the same year Smith described the characteristic features of the disease he termed "infectious lymphocytosis" in a comprehensive report.13 Since his original description reports of cases have been accumulating—in 1958 Crisalli and Terragna were able to find records of almost 400 cases.3 However the disease does not seem to occur as commonly as a perusal of the literature would suggest, and a search failed to reveal any record of


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