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August 1965, Vol 110, No. 2 >
Article | August 1965

Glucose Therapy in Neonatal Respiratory Distress FREE

ANTON LETHIN, MD; VICTOR EISNER, MD
[+] Author Affiliations

Received for publication Jan 26, 1965.

Reprint requests to The Permanente Medical Group, 2425 Geary Blvd, San Francisco, Calif 94115.

The solutions used in the study were supplied by Abbott Laboratories.

Infusion withdrawal pump from Harvard Apparatus Co., Inc., Dover, Mass.


Am J Dis Child. 1965;110(2):140-143. doi:10.1001/archpedi.1965.02090030150006.
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IN 1959, Usher1 and Reardon2 reported that the mortality rate in newborn infants with the idiopathic respiratory distress syndrome could be lowered by intravenous therapy with glucose solutions containing either bicarbonate or saline. The present study was undertaken in an attempt to better define the role that glucose administration plays in the survival of these distressed newborns.

Method  The study was conducted at the Kaiser Foundation Hospital in San Francisco. Infants available for the study were those born in the hospital between Feb 1, 1960 and Feb 1, 1962. Any infant who developed persistent respiratory distress with a Silverman retraction score3 of 2 or more in the first 36 hours of life, was eligible for inclusion in the study. Of the 113 infants fulfilling this requirement, 12 were excluded because the infants' pediatricians elected not to include them in the study. Three infants were excluded from the

REFERENCES

1 +
Usher, R.:  The Respiratory Distress Syndrome of Prematurity: I. Changes in Potassium in the Serum and the Electrocardiogram and Effects of Therapy , Pediatrics 24:562-576, 1959;.
2 +
Reardon, H.S.: " Biochemical Studies and Management of Infants of Diabetic Mothers ," in Report of 31st Ross Conference on Pediatric Research , Columbus, Ohio: Ross Laboratories, 1959;, pp 72-77.
3 +
Silverman, W.A., and Andersen, D.H.:  A Controlled Clinical Trial of Effects of Water Mist on Obstructive Respiratory Signs, Death Rate and Necropsy Findings Among Premature Infants , Pediatrics 17:1-10, 1956;.
4 +
Smith, C.A.: The Physiology of the Newborn Infant , ed 3, Springfield, Ill: Charles C Thomas, Publisher, 1959;, pp 270-279.
5 +
Butterfield, J.; O'Brien, D.; and Lubchenco, L.O.:  Respiratory Distress Syndrome in Premature Infants: An Evaluation of the Early Feeding of Glucose Water , Amer J Dis Child 104: 230-234, 1962;.
6 +
Bauman, W.A.:  Early Feeding of Dextrose and Saline Solution to Premature Infants , Pediatrics 26:756-761, 1960;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Usher, R.:  The Respiratory Distress Syndrome of Prematurity: I. Changes in Potassium in the Serum and the Electrocardiogram and Effects of Therapy , Pediatrics 24:562-576, 1959;.
2 +
Reardon, H.S.: " Biochemical Studies and Management of Infants of Diabetic Mothers ," in Report of 31st Ross Conference on Pediatric Research , Columbus, Ohio: Ross Laboratories, 1959;, pp 72-77.
3 +
Silverman, W.A., and Andersen, D.H.:  A Controlled Clinical Trial of Effects of Water Mist on Obstructive Respiratory Signs, Death Rate and Necropsy Findings Among Premature Infants , Pediatrics 17:1-10, 1956;.
4 +
Smith, C.A.: The Physiology of the Newborn Infant , ed 3, Springfield, Ill: Charles C Thomas, Publisher, 1959;, pp 270-279.
5 +
Butterfield, J.; O'Brien, D.; and Lubchenco, L.O.:  Respiratory Distress Syndrome in Premature Infants: An Evaluation of the Early Feeding of Glucose Water , Amer J Dis Child 104: 230-234, 1962;.
6 +
Bauman, W.A.:  Early Feeding of Dextrose and Saline Solution to Premature Infants , Pediatrics 26:756-761, 1960;.

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