July 1965, Vol 110, No. 1 >

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Article | July 1965

DIENCEPHALIC NEOPLASMS

RUSSELL D. SNYDER, MD

Am J Dis Child. 1965;110(1):109-110. doi:10.1001/archpedi.1965.02090030115023.

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To the Editor: Gareis and Johnson, in their article on intracranial neoplasms and the diencephalic syndrome (Amer J Dis Child 109:349 [Apr] 1965), demonstrate superbly in the first two figures the facial expression which may be characteristic of the syndrome. Braun and Forney¹ and Dods² have photographed patients who demonstrate a marked similarity in facial expression to the patient of Gareis and Johnson. Gareis and Johnson describe the expression as "surprisingly cheerful"; others have noted "definite alertness,"¹ "amazingly alert,"² and "eager over-alertness."³

The feature which causes the alert expression of infants with diencephalic neoplasms would appear to be a retraction of the eyelids. Retraction of the lids is generally referred to as Collier's sign⁴ and is seen in association with lesions of the upper brain stem.

The presence of Collier's sign in an infant with failures to thrive should immediately lead the physician to

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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SNYDER RD. DIENCEPHALIC NEOPLASMS. Am J Dis Child. 1965;110(1):109-110. doi:10.1001/archpedi.1965.02090030115023.

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