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RESPIRATORY DISTRESS SYNDROME AND MAGNESIUM SULPHATE

WILLIAM F. MCGUIRE, MD; HERBERT R. GOLDBERG, MD
Am J Dis Child. 1965;109(6):586. doi:10.1001/archpedi.1965.02090020588018.
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ABSTRACT

To the Editor: After reading the exchange of letters in the recent pediatric literature and the articles in the lay press, we believe it is imperative at this time to impart our experience with magnesium sulfate enemas for the treatment of the respiratory distress syndrome.

We first read with interest the report published in Medical Tribune on Nov 11, 1964. Personal communication with Dr. Daniel Stowens reassured us of his "gratifying" results and benignity of the procedure he outlined. Thus, we used the following approach to therapy in two newborn infants, one a 7 lb (3,175 gm) term infant, the other a 3½ lb (1,534 gm) premature infant. Both infants died. Both infants showed signs of clinical dehydration and increased respiratory depression at short intervals after the magnesium sulfate enemas. Actually, one of the infants had a transient respiratory arrest requiring resuscitation after the colon-filling enema was completed. Electrolyte studies

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