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Imipramine (Tofranil) In the Control of Enuresis

Am J Dis Child. 1965;109(5):412-415. doi:10.1001/archpedi.1965.02090020414006.
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RECENT studies have demonstrated that imipramine (Tofrānil),* an antidepressant agent, is effective in controlling enuresis in children.1-9 These accounts have appeared mainly in the psychiatric literature. The aim of this paper is to acquaint the pediatrician with the nature of the drug and its use in the control of enuresis and to report our results with imipramine in a small group of enuretic children.

Imipramine, a dibenzazepine derivative, is not a monoamine oxidase inhibitor. Its antidepressant effect has been attributed to activation of adrenergic mechanisms in the reticular formation of the brain stem.10 Chemically, it is similar in structure to the phenothiazines and has the following structural formula:

Since imipramine is widely used in the treatment of depression, its side effects have been amply documented. Though the drug is well tolerated


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