We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The de Lange Syndrome

Am J Dis Child. 1965;109(4):325-332. doi:10.1001/archpedi.1965.02090020327012.
Text Size: A A A
Published online


CONGENITAL disorders associated with failure of physical and mental development are common and their pathogenesis is seldom well understood. The finding of abnormal karyogram in certain congenital disorders has added a new dimension in our understanding of these syndromes and renewed the interest in others that have remained in obscurity for many years. The de Lange syndrome originally described in 1933 by Cornelia de Lange1 was, until recently, only recognized in continental Europe. The number of reported cases has increased in 1963 mainly due to contributions from Great Britain and the United States.

In the present paper, we shall report six additional cases of this syndrome.*

Report of Cases  Case 1.—A white girl, the second child of healthy young parents (31 and 30 years old), was born four weeks before the estimated date of confinement. One sister of the patient was born four years before her, and a


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.