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April 1965, Vol 109, No. 4 >
Article | April 1965

Li Human Growth Hormone Administration in Gonadal Dysgenesis FREE

JOHN J. HUTCHINGS, MD; ROBERTO F. ESCAMILLA, MD; CHOH HAO LI, PhD; PETER H. FORSHAM, MD
[+] Author Affiliations

Received for publication Oct 2, 1964.

Reprint requests to Department of Pediatrics, University of California, San Francisco Medical Center, San Francisco, Calif 94122 (Dr. Hutchings).

Supported by a grant from the Jefferson McCleod Moore Fund at the University of California School of Medicine in San Francisco.

δ Dr. Howard Steinbach made these readings.


Am J Dis Child. 1965;109(4):318-321. doi:10.1001/archpedi.1965.02090020320010.
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References
Comments

HUMAN growth hormone (HGH) administered to children with hypopituitarism has an anabolic effect and increases the rate of linear growth without undue stimulation of bony maturation.1,2 Short-term balance studies in individuals with intact pituitary function have demonstrated an anabolic effect, but attempts to stimulate growth have produced inconsistent results.3,4 Although growth retardation due to hypopituitarism is relatively infrequent, a number of children have constitutional dwarfing of various other types, in whom an agent which can produce growth would be most useful.

This is a report of our study of the effect of HGH (Li) on linear growth in two patients with gonadal dysgenesis.

Procedure  The HGH used in this study was prepared by the Li method5 from pituitaries acquired by the Pituitary Bank of the University of California-San Francisco Medical Center.* The HGH, a dry powder, was dissolved in saline solution and passed through a Millipore filter,

REFERENCES

1 +
Hutchings, J. J., et al:  Metabolic Changes Produced by Human Growth Hormone (Li) in Pituitary Dwarf , J Clin Endocr 19:759, 1959;.
2 +
Escamilla, R. F., et al:  Long-Term Effects of Human Growth Hormone (Li) in Pituitary Dwarf , J Clin Endocr 21:721, 1961;.
3 +
Raben, M. S.:  Growth Hormone: II. Clinical Use of Human Growth Hormone , New Eng J Med 266:82, 1962;.
4 +
Finkel, M. J.:  Human Growth Hormone, Metabolic Effects and Experimental and Therapeutic Applications , Amer J Med 32:588, 1962;.
5 +
Li, C. H., and Papkoff, H.:  Preparation and Properties of Growth Hormone From Human and Monkey Pituitary Glands , Science 124:1293, 1956;.
6 +
Li, C. H.; Papkoff, H.; and Hayashida, T.:  Preparation and Properties of Beef-A-Core From Chymotryptic Digestion of Bovine Growth Hormone , Arch Biochem Biophys 85:97, 1959;.
7 +
Tanner, J. M.: Effect of Human Growth Hormone Upon Growth and Skeletal Development in Dwarfed Children With Retarded Bone Age, Abstracts of the Tenth International Congress of Pediatrics, Lisbon: 1963, p 196.
8 +
Hutchings, J. J.: Unpublished data, 1962-1963.
9 +
Forbes, A. P., et al:  Studies of Growth Arrest in Gonadal Dysgenesis: Response to Exogenous Human Growth Hormone , Metabolism 11:56, 1962;.
10 +
de la Chapelle, A.:  Cytogenetical and Clinical Observations in Female Gonadal Dysgenesis , Acta Endocr 400 ( (suppl 65) ):1, 1962;.
11 +
Grossman, E. R.:  Pituitary Gonadotropins in Gonadal Dysgenesis: Age of Appearance and Variability in Amount of Follicle-Stimulating Hormone (FSH) in Urine , Pediatrics 25:298, 1960;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Hutchings, J. J., et al:  Metabolic Changes Produced by Human Growth Hormone (Li) in Pituitary Dwarf , J Clin Endocr 19:759, 1959;.
2 +
Escamilla, R. F., et al:  Long-Term Effects of Human Growth Hormone (Li) in Pituitary Dwarf , J Clin Endocr 21:721, 1961;.
3 +
Raben, M. S.:  Growth Hormone: II. Clinical Use of Human Growth Hormone , New Eng J Med 266:82, 1962;.
4 +
Finkel, M. J.:  Human Growth Hormone, Metabolic Effects and Experimental and Therapeutic Applications , Amer J Med 32:588, 1962;.
5 +
Li, C. H., and Papkoff, H.:  Preparation and Properties of Growth Hormone From Human and Monkey Pituitary Glands , Science 124:1293, 1956;.
6 +
Li, C. H.; Papkoff, H.; and Hayashida, T.:  Preparation and Properties of Beef-A-Core From Chymotryptic Digestion of Bovine Growth Hormone , Arch Biochem Biophys 85:97, 1959;.
7 +
Tanner, J. M.: Effect of Human Growth Hormone Upon Growth and Skeletal Development in Dwarfed Children With Retarded Bone Age, Abstracts of the Tenth International Congress of Pediatrics, Lisbon: 1963, p 196.
8 +
Hutchings, J. J.: Unpublished data, 1962-1963.
9 +
Forbes, A. P., et al:  Studies of Growth Arrest in Gonadal Dysgenesis: Response to Exogenous Human Growth Hormone , Metabolism 11:56, 1962;.
10 +
de la Chapelle, A.:  Cytogenetical and Clinical Observations in Female Gonadal Dysgenesis , Acta Endocr 400 ( (suppl 65) ):1, 1962;.
11 +
Grossman, E. R.:  Pituitary Gonadotropins in Gonadal Dysgenesis: Age of Appearance and Variability in Amount of Follicle-Stimulating Hormone (FSH) in Urine , Pediatrics 25:298, 1960;.

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