We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Precocious Menstruation In Hypothyroidism

Am J Dis Child. 1965;109(3):252-254. doi:10.1001/archpedi.1965.02090020254010.
Text Size: A A A
Published online


THE ASSOCIATION of sexual precocity and hypothyroidism was first reported in 1905.1 Since that time ten cases have been documented, most of which have been published within the past five years.2-8

This communication concerns a child who developed hypothyroidism at approximately 9 years of age. Her first menstrual period occurred within 12 months of the onset of symptoms. Periodic menstruation continued until she was again euthyroid after thyroid replacement therapy. Clinical evidence of sexual precocity subsided after the hypothyroidism was adequately treated, there being no recurrence of menstruation over the year since thyroid replacement was begun.

Previously reported cases will be briefly reviewed.

Report of a Case  The patient, a 10½-year-old female, was first seen in the pediatric endocrine clinic at the age of 9 years 10 months for precocious menstruation and rapid weight gain. Her first menstrual period had occurred four months prior to her initial visit.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.