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December 1964, Vol 108, No. 6 >
Article | December 1964

Herpes Simplex Encephalitis FREE

THOMAS H. KENT, MD; DONALD P. NICHOLSON, MD
[+] Author Affiliations

Received for publication June 23, 1964.

Supported in part by United States Public Health Service grants 2G-168 and 2F2 CA-15, 566-02.


Am J Dis Child. 1964;108(6):644-647. doi:10.1001/archpedi.1964.02090010646010.
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Encephalitis caused by herpes simplex virus has been substantiated rarely in man. Criteria for definitive diagnosis include (1) clinical findings of acute encephalitis, (2) the presence of necrotizing brain lesions with eosinophilic intranuclear inclusions, and (3) isolation of herpes simplex virus from the brain lesions. According to Booth et al,1 there were 11 substantiated cases and 30 probable cases in children and adults reported to 1961.

In children, two patterns of herpes simplex encephalitis have occurred: (1) predominantly central nervous system lesions and (2) central nervous system lesions associated with necrotizing hepato-adrenal lesions. Skin lesions may or may not be present. Herpes simplex virus has been isolated from four cases of the first type2-5 and one case of the second type.6

Herpes simplex encephalitis may be more common than is reported, because virus isolation procedures are not commonly performed and the characteristics of the histology may not

REFERENCES

1 +
Booth, C. B.; Okazaki, H.; and Gaulin, J. C.:  Acute Inclusion Encephalitis of Herpes Simplex Type , Neurology 11:619, 1961;.
2 +
Smith, M. G.; Lennette, E. H.; and Reames, H. R.:  Isolation of Virus of Herpes Simplex and Demonstration of Intranuclear Inclusions in Case of Acute Encephalitis , Amer J Path 17:55, 1941;.
3 +
Ginder, D. R., and Whorton, C. M.:  Herpes Simplex Encephalitis , J Pediat 39:298, 1951;.
4 +
Wildi, E.:  Encéphalite herpétique du nouveauné , Rev Neurol (Paris) 84:201, 1951;.
5 +
Kerenyi, N.; Faulkner, R.; and Petite, E.:  Herpes Simplex Encephalitis: Fatal Case , Canad Med Ass J 81:1011, 1959;.
6 +
Zuelzer, W. W., and Stulberg, C. S.:  Herpes Simplex Virus as Cause of Fulminating Visceral Disease and Hepatitis in Infancy: Report of Eight Cases and Isolation of Virus in One Case , AMA Amer J Dis Child 83:421, 1952;.
7 +
Haymaker, W., et al: Viral Encephalitis , W. S. Fields and R. J. Blattner, ed., Springfield, Ill: Charles C Thomas, Publisher, 1958;, pp 95-204.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Booth, C. B.; Okazaki, H.; and Gaulin, J. C.:  Acute Inclusion Encephalitis of Herpes Simplex Type , Neurology 11:619, 1961;.
2 +
Smith, M. G.; Lennette, E. H.; and Reames, H. R.:  Isolation of Virus of Herpes Simplex and Demonstration of Intranuclear Inclusions in Case of Acute Encephalitis , Amer J Path 17:55, 1941;.
3 +
Ginder, D. R., and Whorton, C. M.:  Herpes Simplex Encephalitis , J Pediat 39:298, 1951;.
4 +
Wildi, E.:  Encéphalite herpétique du nouveauné , Rev Neurol (Paris) 84:201, 1951;.
5 +
Kerenyi, N.; Faulkner, R.; and Petite, E.:  Herpes Simplex Encephalitis: Fatal Case , Canad Med Ass J 81:1011, 1959;.
6 +
Zuelzer, W. W., and Stulberg, C. S.:  Herpes Simplex Virus as Cause of Fulminating Visceral Disease and Hepatitis in Infancy: Report of Eight Cases and Isolation of Virus in One Case , AMA Amer J Dis Child 83:421, 1952;.
7 +
Haymaker, W., et al: Viral Encephalitis , W. S. Fields and R. J. Blattner, ed., Springfield, Ill: Charles C Thomas, Publisher, 1958;, pp 95-204.

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