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December 1964, Vol 108, No. 6 >
Article | December 1964

Infantile Hypertrophic Pyloric Stenosis In Four Siblings FREE

RONALD E. BURMEISTER, MC USN; HOWARD B. HAMILTON, MD
[+] Author Affiliations

Received for publication June 26, 1964.

Howard B. Hamilton, MD, ABCC, MCAS Navy 955, San Francisco, Calif 96638.

Marine Corps Air Station Hospital, Iwakuni, Japan (Dr. Burmeister); Chief, Clinical Laboratories, Atomic Bomb Casualty Commission, Hiroshima and Nagasaki, Japan (Dr. Hamilton).

The Atomic Bomb Casualty Commission is a cooperative research agency of the United States National Academy of Sciences, National Research Council, and Japanese National Institute of Health of the Ministry of Health and Welfare with funds provided by the United States Atomic Energy Commission, the Japanese National Institute of Health, and the United States Public Health Service.


Am J Dis Child. 1964;108(6):617-624. doi:10.1001/archpedi.1964.02090010619006.
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Comments

Infantile (or congenital) hypertrophic pyloric stenosis is a fairly common pediatric disease in the United States and Northern Europe, with an estimated frequency between one to three cases per 1,000 live births and a sex ratio of four or five to one favoring males.1-4 Up to a generation ago, the risk among siblings of affected children could be estimated, but not among their offspring, because of high infant mortality from the disease. With the introduction, in 1912, of pyloromyotomy as definitive treatment,5 increased numbers of affected individuals survive and produce families, permitting study of parents and children with the disease. Even so, familial occurrence is low, as shown by one author who, adding his own cases to those found in a search of the world literature, was able to list in some detail less than 120 families in which there were two or more verified instances of pyloric

REFERENCES

1 +
Cameron, A. L.:  Familial Occurrence of Congenital Hypertrophic Pyloric Stenosis , AMA Arch Surg 70:877-894, 1955;.
2 +
Hayes, M. A., and Goldenberg, I. S.:  Problems of Infantile Pyloric Stenosis , Int Abstr Surg 104: 105-138, 1957;.
3 +
Laron, Z., and Horne, L. M.:  Incidence of Infantile Pyloric Stenosis , AMA J Dis Child 94: 151-154, 1957;.
4 +
Carter, C. O.:  Inheritance of Congenital Pyloric Stenosis , Brit Med Bull 17:251-254, 1961;.
5 +
Rammstedt, W. C.:  Zur Operation der angeborenen Pylorusstenose , Med Klin (Berl) 8: 1702-1705, 1912;.
6 +
Gailey, A. A.:  Congenital Hypertrophic Pyloric Stenosis: Report of Four Cases in Brothers , Brit Med J 1:100-101, 1948;.
7 +
Christiaens, L., and Lanthier, P.:  Quatrième stenose hypertrophique du pylore dans le méme fratrie , Lille Chir 6:123-125, 1951;,
8 +
cited by Cameron, A. L.:  Familial Occurrence of Congenital Hypertrophic Pyloric Stenosis , AMA Arch Surg 70:877-894, 1955;.
9 +
Hungerford, D. A., et al:  Chromosome Constitution of Human Phenotypic Intersex , Amer J Hum Genet 3:215-236, 1959;.
10 +
Williams, H. J.:  Hypertrophic Pyloric Stenosis: Brief Review and Report in Premature Twins , Amer J Roentgen 89:1042-1047, 1963;.
11 +
Wilson, M.:  Pyloric Stenosis in Premature Infants , J Pediat 56:490-497, 1960;.
12 +
MacMahon, B.; Record, R. G.; and McKeown, T.:  Congenital Pyloric Stenosis: Investigation of 578 Cases , Brit J Soc Med 5:185-192, 1951;.
13 +
Mutrakos, J. D.:  Congenital Hypertrophic Pyloric Stenosis in Twins , Arch Dis Child 28:351-358, 1953;.
14 +
Wallgren, A.:  Preclinical Stage of Infantile Hypertrophic Pyloric Stenosis , Amer J Dis Child 72:371-376, 1946;.
15 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Size of Tumor in Infantile Pyloric Stenosis Related to Age at Operation , Lancet 261:556-558, 1951;.
16 +
Gerrard, J. W.; Waterhouse, J. A. H.; and Maurice, D. G.:  Infantile Pyloric Stenosis , Arch Dis Child 30:493-496, 1955;.
17 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Evidence of Post-Natal Environmental Influence in Etiology of Infantile Pyloric Stenosis , Arch Dis Child 27:386-390, 1952;.
18 +
Ford, N.; Ross, M. A.; and Brown, A.:  Primogeniture as Etiologic Factor in Pyloric Stenosis , Amer J Dis Child 61:747-751, 1941;.
19 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Incidence of Congenital Pyloric Stenosis Related to Birth Rank and Maternal Age , Ann Eugen 16:249-259, 1951;.
20 +
Torgersen, J.:  Developmental Anatomy of Pyloric Canal and Etiology of Infantile Pyloric Stenosis , Acta Radiol (Stockholm) 32:435-438, 1949;.
21 +
Cockayne, E. A., and Penrose, L. S.:  Genetics of Congenital Pyloric Stenosis , Ohio J Sci 43:1-16, 1943;.
22 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Familial Incidence of Congenital Pyloric Stenosis , Ann Eugen 16:261-281, 1951;.
23 +
McKeown, T., and MacMahon, B.:  Infantile Hypertrophic Pyloric Stenosis in Parent and Child , Arch Dis Child 30:497-500, 1955;.
24 +
Carter, C. O., and Savage, T. R.:  Pyloric Stenosis in Four Cousins , Arch Dis Child 26:50-51, 1951;.
25 +
Sale, T. A.:  Congenital Hypertrophic Pyloric Stenosis in Twins , Brit Med J 1:920, 1953;.
26 +
Powell, B. W., and Carter, C. O.:  Pyloric Stenosis in Twins , Arch Dis Child 26:45-49, 1951;.
27 +
Laubscher, J. H., and Smith, A. M.:  Pyloric Stenosis in Twins: Review of Literature and Report of Case , Amer J Dis Child 73:334-341, 1947;.
28 +
Carter, C. O., and Powell, B. W.:  Two Generation Pyloric Stenosis , Lancet 266:746-748, 1954;.
29 +
Knox, G.:  On Nature of Determinants of Congenital Pyloric Stenosis , Brit J Prev Soc Med 12:188-192, 1958;.
30 +
Bellefeuille, P.:  Theorem on Genetics of Some Congenital Malformations , Acta Genet (Basel) 12:123-135, 1962;.
31 +
Fraser Roberts, J. A.:  "Multifactorial Inheritance and Human Disease,"  in Steinberg, A. G., and Bearn, A. G., ed.: Progress in Medical Genetics , vol 3, New York: Grune & Stratton, Inc., 1964;, pp 178-216.
32 +
Fraser, F. C.:  Thoughts on Etiology of Clefts of Palate and Lip , Acta Genet (Basel) 5:358-369, 1955;.
33 +
Knox, G., and Braithwaite, F.:  Cleft Lips and Palates in Northumberland and Durham , Arch Dis Child 38:66-70, 1963;.
34 +
Woolf, C. M.; Woolf, R. M.; and Broadbent, T. R.:  Genetics Study of Cleft Lip and Palate in Utah , Amer J Hum Genet 15:209-215, 1963;.
35 +
Race, R. R., and Sanger, R.: Blood Groups in Man , Philadelphia: F. A. Davis Company, 1962;, pp 393-394.
36 +
Morton, N. E.:  Detection and Estimation of Linkage Between Genes for Elliptocytosis and Rh Blood Type , Amer J Hum Genet 8:80-96, 1956;.
37 +
Lejeun, J.: " Congenital Abnormalities With Apparently Normal Chromosome Complement ," cited as a personal communication by Harnden, D. G., in Davidson, W. M., and Smith, D. R., ed.: Proceedings of Conference on Human Chromosomal Abnormalities , Springfield, Ill: Charles C Thomas, Publisher, 1961;, chap 14, p 128.
38 +
Shaw, M. W.:  Familial Mongolism , Cytogenetics (Basel) 1:141-179, 1962;.
39 +
Dekaban, A. S.; Bender, M. A.; and Economos, G. E.:  Chromosome Studies in Mongoloids and Their Families , Cytogenetics (Basel) 2:61-75, 1963;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Cameron, A. L.:  Familial Occurrence of Congenital Hypertrophic Pyloric Stenosis , AMA Arch Surg 70:877-894, 1955;.
2 +
Hayes, M. A., and Goldenberg, I. S.:  Problems of Infantile Pyloric Stenosis , Int Abstr Surg 104: 105-138, 1957;.
3 +
Laron, Z., and Horne, L. M.:  Incidence of Infantile Pyloric Stenosis , AMA J Dis Child 94: 151-154, 1957;.
4 +
Carter, C. O.:  Inheritance of Congenital Pyloric Stenosis , Brit Med Bull 17:251-254, 1961;.
5 +
Rammstedt, W. C.:  Zur Operation der angeborenen Pylorusstenose , Med Klin (Berl) 8: 1702-1705, 1912;.
6 +
Gailey, A. A.:  Congenital Hypertrophic Pyloric Stenosis: Report of Four Cases in Brothers , Brit Med J 1:100-101, 1948;.
7 +
Christiaens, L., and Lanthier, P.:  Quatrième stenose hypertrophique du pylore dans le méme fratrie , Lille Chir 6:123-125, 1951;,
8 +
cited by Cameron, A. L.:  Familial Occurrence of Congenital Hypertrophic Pyloric Stenosis , AMA Arch Surg 70:877-894, 1955;.
9 +
Hungerford, D. A., et al:  Chromosome Constitution of Human Phenotypic Intersex , Amer J Hum Genet 3:215-236, 1959;.
10 +
Williams, H. J.:  Hypertrophic Pyloric Stenosis: Brief Review and Report in Premature Twins , Amer J Roentgen 89:1042-1047, 1963;.
11 +
Wilson, M.:  Pyloric Stenosis in Premature Infants , J Pediat 56:490-497, 1960;.
12 +
MacMahon, B.; Record, R. G.; and McKeown, T.:  Congenital Pyloric Stenosis: Investigation of 578 Cases , Brit J Soc Med 5:185-192, 1951;.
13 +
Mutrakos, J. D.:  Congenital Hypertrophic Pyloric Stenosis in Twins , Arch Dis Child 28:351-358, 1953;.
14 +
Wallgren, A.:  Preclinical Stage of Infantile Hypertrophic Pyloric Stenosis , Amer J Dis Child 72:371-376, 1946;.
15 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Size of Tumor in Infantile Pyloric Stenosis Related to Age at Operation , Lancet 261:556-558, 1951;.
16 +
Gerrard, J. W.; Waterhouse, J. A. H.; and Maurice, D. G.:  Infantile Pyloric Stenosis , Arch Dis Child 30:493-496, 1955;.
17 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Evidence of Post-Natal Environmental Influence in Etiology of Infantile Pyloric Stenosis , Arch Dis Child 27:386-390, 1952;.
18 +
Ford, N.; Ross, M. A.; and Brown, A.:  Primogeniture as Etiologic Factor in Pyloric Stenosis , Amer J Dis Child 61:747-751, 1941;.
19 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Incidence of Congenital Pyloric Stenosis Related to Birth Rank and Maternal Age , Ann Eugen 16:249-259, 1951;.
20 +
Torgersen, J.:  Developmental Anatomy of Pyloric Canal and Etiology of Infantile Pyloric Stenosis , Acta Radiol (Stockholm) 32:435-438, 1949;.
21 +
Cockayne, E. A., and Penrose, L. S.:  Genetics of Congenital Pyloric Stenosis , Ohio J Sci 43:1-16, 1943;.
22 +
McKeown, T.; MacMahon, B.; and Record, R. G.:  Familial Incidence of Congenital Pyloric Stenosis , Ann Eugen 16:261-281, 1951;.
23 +
McKeown, T., and MacMahon, B.:  Infantile Hypertrophic Pyloric Stenosis in Parent and Child , Arch Dis Child 30:497-500, 1955;.
24 +
Carter, C. O., and Savage, T. R.:  Pyloric Stenosis in Four Cousins , Arch Dis Child 26:50-51, 1951;.
25 +
Sale, T. A.:  Congenital Hypertrophic Pyloric Stenosis in Twins , Brit Med J 1:920, 1953;.
26 +
Powell, B. W., and Carter, C. O.:  Pyloric Stenosis in Twins , Arch Dis Child 26:45-49, 1951;.
27 +
Laubscher, J. H., and Smith, A. M.:  Pyloric Stenosis in Twins: Review of Literature and Report of Case , Amer J Dis Child 73:334-341, 1947;.
28 +
Carter, C. O., and Powell, B. W.:  Two Generation Pyloric Stenosis , Lancet 266:746-748, 1954;.
29 +
Knox, G.:  On Nature of Determinants of Congenital Pyloric Stenosis , Brit J Prev Soc Med 12:188-192, 1958;.
30 +
Bellefeuille, P.:  Theorem on Genetics of Some Congenital Malformations , Acta Genet (Basel) 12:123-135, 1962;.
31 +
Fraser Roberts, J. A.:  "Multifactorial Inheritance and Human Disease,"  in Steinberg, A. G., and Bearn, A. G., ed.: Progress in Medical Genetics , vol 3, New York: Grune & Stratton, Inc., 1964;, pp 178-216.
32 +
Fraser, F. C.:  Thoughts on Etiology of Clefts of Palate and Lip , Acta Genet (Basel) 5:358-369, 1955;.
33 +
Knox, G., and Braithwaite, F.:  Cleft Lips and Palates in Northumberland and Durham , Arch Dis Child 38:66-70, 1963;.
34 +
Woolf, C. M.; Woolf, R. M.; and Broadbent, T. R.:  Genetics Study of Cleft Lip and Palate in Utah , Amer J Hum Genet 15:209-215, 1963;.
35 +
Race, R. R., and Sanger, R.: Blood Groups in Man , Philadelphia: F. A. Davis Company, 1962;, pp 393-394.
36 +
Morton, N. E.:  Detection and Estimation of Linkage Between Genes for Elliptocytosis and Rh Blood Type , Amer J Hum Genet 8:80-96, 1956;.
37 +
Lejeun, J.: " Congenital Abnormalities With Apparently Normal Chromosome Complement ," cited as a personal communication by Harnden, D. G., in Davidson, W. M., and Smith, D. R., ed.: Proceedings of Conference on Human Chromosomal Abnormalities , Springfield, Ill: Charles C Thomas, Publisher, 1961;, chap 14, p 128.
38 +
Shaw, M. W.:  Familial Mongolism , Cytogenetics (Basel) 1:141-179, 1962;.
39 +
Dekaban, A. S.; Bender, M. A.; and Economos, G. E.:  Chromosome Studies in Mongoloids and Their Families , Cytogenetics (Basel) 2:61-75, 1963;.

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