Uracil Mustard Therapy in Metastatic Wilms's Tumor FREE

T. J. VIETTI, MD; D. H. BERRY, MD; D. J. FERNBACH, MD; J. LUSHER, MD; W. W. SUTOW, MD

Received for publication July 7, 1964.

T. J. Vietti, MD, 500 S Kingshighway, St. Louis, Mo 63110.

This study was supported by grant CA-03754 from the Clinical Branch, Collaborative Research, National Cancer Institute, United States Public Health Service, Bethesda, Md.

Committee of the Pediatric Division of The Southwest Cancer Chemotherapy Study Group, composed of the principal investigators (names first) and their associates at the following institutions: Baylor University College of Medicine, Houston: R. J. Blattner, MD, and D. J. Fernbach, MD; Emory University School of Medicine, Atlanta: W. G. Thurman, MD, and W. L. Watkins, MD; The University of Oklahoma Medical Center, Oklahoma City: H. D. Riley, Jr., MD, and T. B. Haddy, MD; The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston: Grant Taylor, MD, W. W. Sutow, MD, and M. P. Sullivan, MD; The University of Texas Medical Branch, Galveston, Tex: C. W. Daeschner, MD, and M. E. Haggard, MD; The University of Texas Southwestern Medical School, Dallas: E. L. Pratt, MD, J. A. Whitaker, MD, and Joan Windmiller, MD; Tulane University School of Medicine, New Orleans: C. C. Sprague, MD, and Jeanne Lusher, MD; University of Arkansas Medical Center, Little Rock: T. C. Panos, MD, F. S. Porter, MD, and D. H. Berry, MD; Washington University School of Medicine, Saint Louis: A. F. Hartmann, MD, Jean Holowach, MD, and T. J. Vietti, MD; Wilford Hall USAF Hospital, Lackland Air Force Base, Tex: T. M. Holcomb, MD; Southwest Cancer Chemotherapy Study Group Headquarters, Houston: K. M. Griffith, MD.

Am J Dis Child. 1964;108(5):530-532. doi:10.1001/archpedi.1964.02090010532012.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

The therapeutic effectiveness of uracil mustard, 5 [bis (2 chloroethyl) amino] uracil, was evaluated by the Southwest Cancer Chemotherapy Study Group in children with metastatic Wilms's tumor. This clinical trial was conducted in accordance with the Group's "sensitivity spectrum" protocol for the systematic investigation of new agents against solid tumors of childhood.¹

Uracil mustard, an oral alkylating agent, is a substituted mechlorethamine hydrochloride (nitrogen mustard). In comparative experiments on animal tumors, uracil mustard was more effective than either chlorambucil or nitrogen mustard.^2,3 This enhanced activity is thought to be due to an increased uptake of the uracil mustard into the desoxyribonucleic acid molecule because of the carrier action of uracil. There is no evidence that it acts as a uracil antagonist. In human malignancies it has been shown to be effective against chronic leukemias, lymphomas, and, occasionally, carcinoma of the lung and ovary and other neoplastic diseases.^4-8

REFERENCES

ABSTRACT | REFERENCES

Thurman, W. G., et al: "Sensitivity Spectrum" Protocol for Evaluating Multiple Agents Against Solid Tumors , Cancer Chemother Rep 12:131, 1961;.

Evans, J. S., and Mengel, G. D.: Antitumor Activity of 5-Bis-(2-Chlorethyl)-Amino Uracil Against Sarcoma 180 and Ehrlich Carcinoma , Proc Soc Exp Biol Med 99:620, 1958;.

Lane, M., and Kelly, M. G.: Antitumor Activity of 5-Bis-(2-Chlorethyl)-Aminouracil (Uracil Mustard) , Cancer Res 20:511, 1960;.

Spurr, C., and Hayes, D. M.: Clinical Observations on Newer Chemotherapeutic Agents , Southern Med J 53:1005, 1960;.

Lane, M., et al: Preliminary Report: Observations on Clinical Pharmacology of 5-[Bis-(2-Chloroethyl)-Amino]Uracil , Cancer Chemother Rep 9:31, 1960;.

Shanbrom, E., et al: Therapeutic Spectrum of Uracil Mustard, New Oral Antitumor Drug , JAMA 174:1702, 1960;.

Kennedy, B. J., and Theologides, A.: Uracil Mustard, New Alkylating Agent for Oral Administration in Management of Patients With Leukemia and Lymphoma , New Eng J Med 264:790, 1961;.

Wilkinson, J. F., and Bourne, M. B.: Treatment of Leukaemias and Reticuloses With Uracil Mustard , Brit Med J 1:1563, 1963;.

Porter, F. S.; Holowach, J.; and Thurman, W. G.: Uracil Mustard Therapy in Acute Leukemia in Children , Cancer Chemother Rep 18:79, 1962;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal