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July 1964, Vol 108, No. 1 >
Article | July 1964

SALICYLAMIDE TOXICITY AND SALICYLISM-Reply FREE

PAUL N. TSCHETTER, MD
Am J Dis Child. 1964;108(1):109-110. doi:10.1001/archpedi.1964.02090010111018.
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To The Editor: Dr. Mofenson's comments that salicyamide should not be included in a general category with the other salicylates is well taken. There are several points he makes, however, which need further comment.

Regarding the toxicity of salicylamide the picture is cloudy. Gleason et al state it is less toxic than the other salicylates.1 Done, in reviewing five animal studies, notes there were marked species differences and no agreement as to whether salicylamide is more or less toxic than aspirin. For example, one author Done reviewed stated salicylamide was only 83% as toxic as aspirin in rats, but was 64% more toxic in the mouse. Another worker reported just the reverse, ie, salicylamide was 46% more toxic in the rat and only 80% as toxic in the mouse. Done concludes, "it is apparent that marked species differences preclude making even an intelligent guess as to the comparative toxicities

REFERENCES

1 +
Gleason, M. N.; Gosselin, R. E.; and Hodge, H. C.: Clinical Toxicology of Commercial Products, Acute Poisoning , Baltimore: The Williams & Wilkins Co., 1963;.
2 +
Done, A. K.:  Uses and Abuses of Antipyretic Therapy , Pediatrics 23:774, 1959;.
3 +
Bavin E. M., et al:  Analgesic and Antipyretic Properties of Some Derivatives of Salicylamide , J Pharm Pharmacol 4:872, 1952;.
4 +
Hart, E. R.:  Toxicity and Analgesic Potency of Salicylamide and Certain of Its Derivatives as Compared With Established Analgesic-Antipyretic Drugs , J Pharmacol Exper Ther 89:205, 1947;.
5 +
Goodman, L. S., and Gilman, A.: Pharmacological Basis of Therapeutics , ed 2, New York: The Macmillan Co., 1955;.
6 +
Seeberg, V. P.; Hansen, D.; and Whitney, B.:  Absorption and Distribution of Salicylamide , J Pharm Exper Ther 101:275, 1951;.
7 +
Litter, M.; Moreno, A. R.; and Donin, L.: Salicylamide:  Pharmacology, Fate and Clinical Use , J Pharm Exper Ther 101:119, 1951;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Gleason, M. N.; Gosselin, R. E.; and Hodge, H. C.: Clinical Toxicology of Commercial Products, Acute Poisoning , Baltimore: The Williams & Wilkins Co., 1963;.
2 +
Done, A. K.:  Uses and Abuses of Antipyretic Therapy , Pediatrics 23:774, 1959;.
3 +
Bavin E. M., et al:  Analgesic and Antipyretic Properties of Some Derivatives of Salicylamide , J Pharm Pharmacol 4:872, 1952;.
4 +
Hart, E. R.:  Toxicity and Analgesic Potency of Salicylamide and Certain of Its Derivatives as Compared With Established Analgesic-Antipyretic Drugs , J Pharmacol Exper Ther 89:205, 1947;.
5 +
Goodman, L. S., and Gilman, A.: Pharmacological Basis of Therapeutics , ed 2, New York: The Macmillan Co., 1955;.
6 +
Seeberg, V. P.; Hansen, D.; and Whitney, B.:  Absorption and Distribution of Salicylamide , J Pharm Exper Ther 101:275, 1951;.
7 +
Litter, M.; Moreno, A. R.; and Donin, L.: Salicylamide:  Pharmacology, Fate and Clinical Use , J Pharm Exper Ther 101:119, 1951;.

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