0
July 1964, Vol 108, No. 1 >
Article | July 1964

SALICYLAMIDE TOXICITY AND SALICYLISM FREE

H. C. MOFENSON, MD
Am J Dis Child. 1964;108(1):109. doi:10.1001/archpedi.1964.02090010111016.
Text Size: A A A
Published online
Article
References
Comments

To the Editor: In reading over Dr. Paul N. Tschetter's article on salicylism (Amer J Dis Child 106:334 [Sept] 1963) I encountered a controversial point in that he implied that salicylamide produces the clinical picture of salicylism.

Salicylamide chemically 2-hydroxybenzamide (Liquiprin) has a LD-50 of 1.4 gm per kg in rats. Toxic dose of this drug causes depression of the central nervous system as opposed to stimulation caused by acetylsalicylic acid. It does not alter the prothrombin time and is not hydrolized to salicylic acid. Therefore, salicylate levels are of no value in determining this drug ingestion. It is excreted as glucuronide of salicylamide.

It would appear that this controversial point is carried over from a previous article by Fruthaler and Snyder (Pediat Clin N Amer 9:41, 1962).

REFERENCES

1 +
Little, M., et al:  Salicylamide Pharmacology Fate and Clinical Use , J Pharmacol Exp Ther 101:119-124, 1951;.
2 +
Quick, A. J., and Clesceri, L.:  Influence of Acetylsalicylic Acid and Salicylamide on Coagulation of Blood , J Pharmacol Exp Ther 128:95-98, 1960;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Little, M., et al:  Salicylamide Pharmacology Fate and Clinical Use , J Pharmacol Exp Ther 101:119-124, 1951;.
2 +
Quick, A. J., and Clesceri, L.:  Influence of Acetylsalicylic Acid and Salicylamide on Coagulation of Blood , J Pharmacol Exp Ther 128:95-98, 1960;.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems