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Tolbutamide Tolerance in Hypoglycemic Children

Am J Dis Child. 1964;107(4):417-423. doi:10.1001/archpedi.1964.02080060419015.
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Introduction  The diagnosis of an islet cell tumor in infants and children is challenging because this extremely rare condition can be definitively cured by surgery. Since 1958, Fajans 1-3 and others,4-5 have had remarkable success using the tolbutamide tolerance test (T.T.T.) for the detection of functioning islet cell adenomas in adults. As yet, there has been little application of this test to infants and children. In four children with idiopathic hypoglycemia Fajans 2,3 noted a return to normal fasting range between two and three hours. Klein 6 and co-workers reported results of intravenous tolbutamine on 12 healthy children in 1958. Grumbach and Kaplan 7 reported a normal response to 25 mg/kg tolbutamide in one child with leucine-sensitive hypoglycemia. Recently DiGeorge and Chiowanich 8 obtained normal responses from 15 healthy children and 11 patients with cystic fibrosis. Two infants with hypoglycemia studied by these workers gave responses suggesting adenoma on


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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