To the Editor: We appreciate Dr. Baughman's bringing to our attention this interesting aspect of Turner's syndrome. Masculinization in that disease, however, is not necessarily analogous to the adrenogenital syndrome in males. A review of the patients to whom he has referred shows that none had chromosomal karyograms.
Quite recently, Turner, Greenblatt, and Dominguez reported masculinizing features in two patients with Turner's syndrome which had chromosomal mosaicism (XO/XY) and unilateral testes.1
Turner's syndrome is a different genotype from congenital virilizing adrenal hyperplasia. Turner's is related to absence of one X chromosome, probably due to meiotic nondisjunction in either oogenesis or spermatogenesis.2,3 Congenital virilizing adrenal hyperplasia is one phase of an autosomal recessive condition in the female variant of which a normal female nuclear chromatin pattern is seen.4,5 The karyotype of such a patient is normal female.6
Since a "male" or "negative" chromatin pattern could be based